2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Lipoxygenase PGE synthase
  4. 5-LO/mPGES1-IN-1

5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity.

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5-LO/mPGES1-IN-1 Chemical Structure

5-LO/mPGES1-IN-1 Chemical Structure

CAS No. : 1492060-44-2

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5-LO/mPGES1-IN-1 Related Antibodies

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Description

5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity[1].

IC50 & Target

5-LOX

0.4 μM (IC50)

In Vivo

5-LO/mPGES1-IN-1 (10 mg/kg, intraperitoneally injected, pretreated 30 minutes before peritonitis induction) reduces vascular permeability and inflammatory cell infiltration in zymosan-induced mouse peritonitis models. Impaired cysteine-leukotriene and prostaglandin E2 levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zymosan-Induced Peritonitis in Mice[1]
Dosage: 10 mg/kg
Administration: i.p. pretreated 30 minutes before peritonitis induction
Result: Reduced vascular permeability by 57% and inhibited neutrophil infiltration by 45%.
Molecular Weight

513.07

Formula

C25H25ClN4O2S2
CAS No.
SMILES

O=C(C(CCCCCC)SC1=NC(Cl)=CC(NC2=NC(C3=CC4=C(C=CC=C4)C=C3)=CS2)=N1)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5-LO/mPGES1-IN-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-LO/mPGES1-IN-11492060-44-2LipoxygenasePGE synthaseLOXProstaglandin E synthase5-LOmPGES-1InhibitorZymosan-Induced Peritonitis in MiceAnti-inflammatoryinhibitorinhibit

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