1. Metabolic Enzyme/Protease
  2. ROR
  3. CD12681

CD12681 

Cat. No.: HY-111366
Handling Instructions

CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis.

For research use only. We do not sell to patients.

CD12681 Chemical Structure

CD12681 Chemical Structure

CAS No. : 1952239-59-6

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Description

CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis[1].

IC50 & Target[1]

RORγ

 

In Vitro

CD12681 (compound 14) shows inhibition with IC50s of 44, >25, 9 µM for CYP 3A4, CYP 2D6, hERG, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

471.61

Formula

C25H33N3O4S

CAS No.
SMILES

O=S(C1=CC(NC(N2CC3CCOCC3)=O)=C2C=C1)(N(C4=CC=C(C)C=C4C)CC(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CD12681
Cat. No.:
HY-111366
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