1-Oxomiltirone
2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione is a C20 -norabietane diterpenoid with anti-inflammatory activity. 2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione can be isolated from sage leaves.
For research use only. We do not sell to patients.
- CAS No.: 142546-16-5
- Formula: C19H20O3
- Molecular Weight:296.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
24.89 μM
Compound: 19
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Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| BXPC-3 | GI50 |
20.54 μM
Compound: 19
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Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human BxPC3 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| HL-60 | GI50 |
23.27 μM
Compound: 19
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Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human HL60 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| KB 3-1 | IC50 |
46.6 μM
Compound: 4
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Cytotoxicity against drug-sensitive human KB-3-1 cells after 48 hrs by MTS/PMS assay
Cytotoxicity against drug-sensitive human KB-3-1 cells after 48 hrs by MTS/PMS assay
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[PMID: 11720520] |
| KB-V1 | IC50 |
47.8 μM
Compound: 4
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Cytotoxicity against multidrug-resistant human KBV1 cells after 48 hrs by MTS/PMS assay
Cytotoxicity against multidrug-resistant human KBV1 cells after 48 hrs by MTS/PMS assay
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[PMID: 11720520] |
| MIA PaCa-2 | IC50 |
29.9 μM
Compound: 18
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Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay
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[PMID: 21775156] |
| MRC5 | GI50 |
20.39 μM
Compound: 19
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Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human MRC5 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| PANC-1 | GI50 |
32.15 μM
Compound: 19
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Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PANC1 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| PBMC | IC50 |
44.6 μM
Compound: 4
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Inhibition of phytohemagglutininin A-stimulated human PBMC proliferation assessed as decrease in [14C]thymidine incorporation
Inhibition of phytohemagglutininin A-stimulated human PBMC proliferation assessed as decrease in [14C]thymidine incorporation
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[PMID: 11720520] |
| PC-3 | GI50 |
18.97 μM
Compound: 19
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Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human PC3 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
2-Isopropyl-8,8-dimethyl-7,8-dihydrophenanthrene-3,4,5(6H)-trione (compound 12) has inhibitory effects on LPS-stimulated NO production in RAW264.7 cells with an IC50 value of 5.86 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 142546-16-5
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Molecular Weight 296.36
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Formula C19H20O3
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SMILES
O=C1C(C(C(C)C)=CC2=C1C(C(CCC3(C)C)=O)=C3C=C2)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1-Oxomiltirone Related Classifications
HY-N10703 Related Classifications
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