1. MAPK/ERK Pathway
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  3. Tpl2 Kinase Inhibitor 1

Tpl2 Kinase Inhibitor 1 

Cat. No.: HY-12358 Purity: >99.0%
Handling Instructions

Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers.

For research use only. We do not sell to patients.

Tpl2 Kinase Inhibitor 1 Chemical Structure

Tpl2 Kinase Inhibitor 1 Chemical Structure

CAS No. : 871307-18-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 459 In-stock
Estimated Time of Arrival: December 31
5 mg USD 515 In-stock
Estimated Time of Arrival: December 31
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Description

Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor, plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].

IC50 & Target

MAP3K8

 

In Vitro

Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[1].

Molecular Weight

404.83

Formula

C₂₁H₁₄ClFN₆

CAS No.

871307-18-5

SMILES

N#CC1=C(NC2=CC=C(F)C(Cl)=C2)C3=CC(NCC4=CC=CN=C4)=NC=C3N=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

Tpl2 Kinase Inhibitor 1MAP3KMAP kinase kinase kinase, MEKK, MAPKKKCOTkinaseinflammatorycancerInhibitorinhibitorinhibit

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Product name:
Tpl2 Kinase Inhibitor 1
Cat. No.:
HY-12358
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