2. MAPK/ERK Pathway
  3. MAP3K p38 MAPK MAPKAPK2 (MK2)
  4. Tpl2 Kinase Inhibitor 1 hydrochloride

Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers.

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Tpl2 Kinase Inhibitor 1 hydrochloride

Tpl2 Kinase Inhibitor 1 hydrochloride Estructura química

No. CAS : 2934185-09-6

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Tpl2 Kinase Inhibitor 1 hydrochloride Related Antibodies

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Ver todos los productos específicos de isoformas MAP3K:

Ver todas las isoformas
MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1 MAP3K12/DLK/Pref-1 NIK/MAP3K14

Ver todos los productos específicos de isoformas p38 MAPK:

Ver todas las isoformas
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Descripciòn

Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].

IC50 & Target[1]

MAP3K8/COT/Tpl2

 

p38

180 μM (IC50)

MK2

110 μM (IC50)

In Vitro

Tpl2 (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family that is upstream of MEK in the ERK pathway[1].
Cancer Osaka thyroid (COT) kinase (Tpl2) is an important regulator of pro-inflammatory cytokines in macrophages[2].
Tpl2 Kinase Inhibitor 1 (compound 2p) hydrochloride also inhibits MK2 and p38, with IC50s of 110 μM and 180 μM, respectively in A431 cells[1].
Tpl2 Kinase Inhibitor 1 hydrochloride inhibits lipopolysaccharide-induced TNF-a production from primary human monocytes and human whole-blood, with IC50s of 0.7 μM and 8.5 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tpl2 Kinase Inhibitor 1 hydrochloride Related Antibodies
Peso molecular

441.29

Fòrmula

C21H15Cl2FN6
No. CAS
SMILES

FC1=CC=C(NC2=C(C=NC3=C2C=C(NCC4=CN=CC=C4)N=C3)C#N)C=C1Cl.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Tpl2 Kinase Inhibitor 1 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tpl2 Kinase Inhibitor 12934185-09-6MAP3Kp38 MAPKMAPKAPK2 (MK2)MAP kinase kinase kinase, MEKK, MAPKKKMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2COTkinaseinflammatorycancerInhibitorinhibitorinhibit

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Nombre del producto:
Tpl2 Kinase Inhibitor 1 hydrochloride
Cat. No.:
HY-12358A
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