2934185-09-6
2934185-09-6
Chemical Structure
Tpl2 Kinase Inhibitor 1 hydrochloride
- CAS No.: 2934185-09-6
- Formula:C21H15Cl2FN6
- Molecular Weight:441.29
InChIKey: KEDACRYGOAMPOW-UHFFFAOYSA-N
SMILES: FC1=CC=C(NC2=C(C=NC3=C2C=C(NCC4=CN=CC=C4)N=C3)C#N)C=C1Cl.Cl
Biological Activity: Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].
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Tpl2 Kinase Inhibitor 1 hydrochloride | Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers. | |||||||||||||||||||||
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References
- [1]. Gavrin LK, et al. Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. [Content Brief]
- [2]. Glatthar R, et al. Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem. 2016 Aug 25;59(16):7544-60. [Content Brief]
