Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92. doi: 10.1016/j.bmcl.2005.08.029.
Lori Krim Gavrin  1 ,  Neal Green ,  Yonghan Hu ,  Kristin Janz ,  Neelu Kaila ,  Huan-Qiu Li ,  Steve Y Tam ,  Jennifer R Thomason ,  Ariamala Gopalsamy ,  Greg Ciszewski ,  John W Cuozzo ,  J Perry Hall ,  Sang Hsu ,  Jean-Baptiste Telliez ,  Lih-Ling Lin
Affiliations
  • 1. Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA.
PMID: 16165349 DOI: 10.1016/j.bmcl.2005.08.029
Abstract

The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with significant therapeutic potential for treating rheumatoid arthritis and Other inflammatory diseases.

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