1. Phenylpropanoids

Protocatechualdehyde (Synonyms: Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV)

Cat. No.: HY-N0295
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Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.

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Protocatechualdehyde Chemical Structure

Protocatechualdehyde Chemical Structure

CAS No. : 139-85-5

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Estimated Time of Arrival: December 31
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].

In Vitro

Protocatechualdehyde (PCA) (50, 100 μM, 24/48 hours ) treated MCF-7 cells significantly decrease cell growth by 11% and 20% in 24 hours and by 22% and 27% in 48 hours, respectively[2].
Protocatechualdehyde (50, 100 μM, 24 hours) treated MCF-7 cells are increased by 1.9-fold and 2.6-fold in the concentrations of 50 μM and 100 μM, respectively. PCA suppresses proliferation of estrogen receptor (ER)-positive (MCF-7) breast cancer cells, but not ER-negative (MDA-MB-231) breast cancer cells[2].
Protocatechualdehyde (0, 100, 200 μM, 48 hours in HCT116 and SW480 cells) affects the enzyme activity of HDAC and observed that PCA treatment resulted in inhibition of HDAC activity in dose-dependent manner[3].

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Inhibited MCF-7 cells cell growth.

Apoptosis Analysis[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Increased apoptosis in MCF-7 cells.
References
Molecular Weight

138.12

Formula

C₇H₆O₃

CAS No.

139-85-5

SMILES

O=CC1=CC=C(O)C(O)=C1

Storage

4°C, stored under nitrogen

Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
C1   V1   C2   V2

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Product Name:
Protocatechualdehyde
Cat. No.:
HY-N0295
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Protocatechualdehyde

Cat. No.: HY-N0295