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  3. Protocatechualdehyde

Protocatechualdehyde (Synonyms: Catechaldehyde; Protocatechuic aldehyde; Rancinamycin IV)

Cat. No.: HY-N0295 Purity: 99.92%
Handling Instructions

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent.

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Protocatechualdehyde Chemical Structure

Protocatechualdehyde Chemical Structure

CAS No. : 139-85-5

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Description

Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].

In Vitro

Protocatechualdehyde (PCA) (50, 100 μM, 24/48 hours ) treated MCF-7 cells significantly decrease cell growth by 11% and 20% in 24 hours and by 22% and 27% in 48 hours, respectively[2].
Protocatechualdehyde (50, 100 μM, 24 hours) treated MCF-7 cells are increased by 1.9-fold and 2.6-fold in the concentrations of 50 μM and 100 μM, respectively. PCA suppresses proliferation of estrogen receptor (ER)-positive (MCF-7) breast cancer cells, but not ER-negative (MDA-MB-231) breast cancer cells[2].
Protocatechualdehyde (0, 100, 200 μM, 48 hours in HCT116 and SW480 cells) affects the enzyme activity of HDAC and observed that PCA treatment resulted in inhibition of HDAC activity in dose-dependent manner[3].

Cell Proliferation Assay[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Inhibited MCF-7 cells cell growth.

Apoptosis Analysis[2]

Cell Line: Human breast cancer cell (MCF-7 and MDA-MB-231)
Concentration: 0, 5, 10, 25, 50, and 100 μM
Incubation Time: 24, 48 hours
Result: Increased apoptosis in MCF-7 cells.
Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (362.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.2401 mL 36.2004 mL 72.4008 mL
5 mM 1.4480 mL 7.2401 mL 14.4802 mL
10 mM 0.7240 mL 3.6200 mL 7.2401 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (18.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (18.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (18.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

138.12

Formula

C₇H₆O₃

CAS No.

139-85-5

SMILES

O=CC1=CC=C(O)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Protocatechualdehyde
Cat. No.:
HY-N0295
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Protocatechualdehyde

Cat. No.: HY-N0295