Cat. No.: HY-N0001

(-)-Epicatechin

Name: (-)-Epicatechin
Brand: MedChemExpress
SKU: HY-N0001
Price: 42.00 USD
Availability: InStock
Rating: 5 (17 reviews)

(Synonyms: (-)-Epicatechol; Epicatechin; epi-Catechin)

17 Cited Publications

Avis client

Based on 17 publication(s) in Google Scholar

(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

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Pureté : 98.85%
CAS No.: 490-46-0
Formule: C₁₅H₁₄O₆
Masse moléculaire:290.27

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(-)-Epicatechin Chemical Structure

CAS No.: 490-46-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (17)
Solvant et solubilité
- In Vitro
- In Vivo
Protocole (4)
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

COX-1

3.2 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform COX :

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	>10 μg/mL Compound: 47	Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
BMDC	IC₅₀	>50 μM Compound: 17	Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
BMDC	IC₅₀	>50 μM Compound: 17	Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
BMDC	IC₅₀	>50 μM Compound: 17	Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	[PMID: 25769817]
BV-2	IC₅₀	47.37 μM Compound: 11	Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction Antineuroinflammatory activity in human BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction	[PMID: 27623545]
DLD-1	IC₅₀	>25 μM Compound: 11	Cytotoxicity against human DLD1 cells Cytotoxicity against human DLD1 cells	[PMID: 18039011]
DLD-1	IC₅₀	415 μM Compound: epicatechin	Inhibition of COX2 mRNA expression in human DLD1 cells Inhibition of COX2 mRNA expression in human DLD1 cells	[PMID: 16038536]
HCT-8	ED₅₀	>10 μg/mL Compound: 47	Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
HeLa	IC₅₀	>25 μM Compound: 11	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 18039011]
HUVEC	IC₅₀	>100 μM Compound: 37	Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells Inhibition of NADPH oxidase in Homo sapiens (human) HUVEC cells	10.1007/s00044-012-0353-y
KB	ED₅₀	>10 μg/mL Compound: 47	Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
L929	EC₅₀	300 μM Compound: epicatechin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining	[PMID: 9287415]
L929	EC₅₀	350 μM Compound: epicatechin	Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay	[PMID: 9287415]
LNCaP	EC₅₀	13 μM Compound: 1	Decrease in androgen receptor protein expression in LNCaP cells by Western blotting Decrease in androgen receptor protein expression in LNCaP cells by Western blotting	[PMID: 17383188]
MT4	CC₅₀	136.2 μg/mL Compound: 11	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 10425115]
MT4	IC₅₀	34.1 μg/mL Compound: 11	Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 10425115]
PC-3	IC₅₀	>500 μM Compound: 2	In vitro inhibitory concentration against PC-3 cell line in MTT assay was determined after 3 days incubation In vitro inhibitory concentration against PC-3 cell line in MTT assay was determined after 3 days incubation	[PMID: 15380225]
Platelet	IC₅₀	>50 μg/mL Compound: (-)-epi-Catechin	Antiaggregatory activity in human platelets assessed as inhibition of thrombin-induced platelet aggregation by aggregometry Antiaggregatory activity in human platelets assessed as inhibition of thrombin-induced platelet aggregation by aggregometry	[PMID: 21106454]
Platelet	IC₅₀	22.22 μg/mL Compound: (-)-epi-Catechin	Antiaggregatory activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by aggregometry Antiaggregatory activity in human platelets assessed as inhibition of collagen-induced platelet aggregation by aggregometry	[PMID: 21106454]
SK-OV-3	IC₅₀	>500 μM Compound: 2	In vitro inhibitory concentration against SKOV3 cell line in MTT assay was determined after 3 days incubation In vitro inhibitory concentration against SKOV3 cell line in MTT assay was determined after 3 days incubation	[PMID: 15380225]
TE-671	ED₅₀	>10 μg/mL Compound: 47	Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay	[PMID: 1431932]
U-373MG ATCC	IC₅₀	>500 μM Compound: 2	In vitro inhibitory concentration against U373MG cell line in MTT assay was determined after 3 days incubation In vitro inhibitory concentration against U373MG cell line in MTT assay was determined after 3 days incubation	[PMID: 15380225]
Vero	IC₅₀	184.1 μM Compound: 5	Cytotoxicity against african green monkey Vero cells after 4 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 4 hrs by MTT assay	[PMID: 16724851]

In Vitro

(-)-Epicatechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM^[1]. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. In RINm5F cells, (-)-Epicatechin is shown to block the inhibition of insulin release after addition of IL-1β. Additionally, (-)-Epicatechin is shown to inhibit the proliferation of Hodgkin's lymphoma cells and Jurkat T cells, which is attributed to the ability of (-)-Epicatechin to inhibit the binding of NF-κB to DNA in these cells. In human colorectal cancer HCT-116 cells, combining 20 μM Panaxadiol with 150, 200, or 250 μM (-)-Epicatechin results in growth inhibition of 51%, 97%, and 95%, respectively. The combination also increases the apoptosis level by 11.9%, 16.6%, and 25.8%, as examined by annexin V/PI staining^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

Animals receive 1 mg/kg of (-)-Epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups undergo 15 days of treadmill exercise. Significant increases in treadmill performance (~50%) and enhanced in situ muscle fatigue resistance (~30%) are observed with (-)-Epicatechin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 490-46-0
Appearance Solid
Masse moléculaire 290.27
Formule C₁₅H₁₄O₆
Color White to light yellow
SMILES

O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1
Synonyms

(-)-Epicatechol; Epicatechin; epi-Catechin
Structure Classification
- Flavonoids
- Flavanols
- Phenols
- Polyphenols
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (17)

All Cell Proliferation/Viability AssayMicrobiological AssayIn Vivo Efficacy StudyWBRT-PCRHistological Imaging/StainingCell Imaging/Staining

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Journal Impact Factor

J Adv Res

Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer. [Abstract]

2025 May 17:S2090-1232(25)00347-9. PMID: 40389113

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 17:S2090-1232(25)00347-9. [Abstract]

The survival rates and IC50 of A549-R when treated with (-)-Epicatechin (EC, 5-320 μM, 24-72 h) individually.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 17:S2090-1232(25)00347-9. [Abstract]

(-)-Epicatechin (EC, 5 mg/kg, intraperitoneally injected, once every 3 days for 8 times). Tumor images and tumor weight of each group (n = 6) in A549-R xenograft tumor models.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 17:S2090-1232(25)00347-9. [Abstract]

(-)-Epicatechin (EC, 5 mg/kg, intraperitoneally injected, once every 3 days for 8 times). Tumor volume and body weight of each group during administration in A549 xenograft tumor models.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 May 17:S2090-1232(25)00347-9. [Abstract]

(-)-Epicatechin (EC, 5 mg/kg, intraperitoneally injected, once every 3 days for 8 times). H&E staining of tumor tissues of each group.
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 Oct 15:489:144992. PMID: 40466530
Food Res Int

2026 Jul 20;242:120107.
Anal Chem

Noninvasive Dynamic Cell Viability Monitoring Based on Diffraction Height Fingerprint Spectra. [Abstract]

2025 Dec 19. PMID: 41417584
J Agric Food Chem

(-)-Epicatechin Protects against Fatty Liver Hemorrhagic Syndrome in Laying Hens by Integrating Multitarget Mechanisms via ERα Signaling. [Abstract]

2026 Jun 17;74(23):18051-18071. PMID: 42231735
Ind Crops Prod

2026 May 8;246:123392.
Ind Crops Prod

2025 Dec 11;239:122458.
Int J Mol Sci

Enhanced Anti-Atherogenic Effects of Epicatechin and Hydroxytyrosol in THP-1 Macrophages: An Integrated In Silico and In Vitro Study. [Abstract]

2026 May 10;27(10):4235. PMID: 42196218
J Nutr Biochem

The role of GPER-mediated AMPKα signal in the prevention effect of (-)-epicatechin on metabolic dysfunction-associated steatohepatitis. [Abstract]

2026 Jan:147:110106. PMID: 40935199
Viruses

Antiviral Effect of Epigallocatechin Gallate via Impairing Porcine Circovirus Type 2 Attachment to Host Cell Receptor. [Abstract]

2020 Feb 4;12(2):176. PMID: 32033244

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: Viruses. 2020 Feb 4;12(2):176. [Abstract]

Cytotoxicity assay of soluble EGCG and (-)-Epicatechin (EC). PK-15 cells were added with a concentration of 0, 10, 50, 100 and 200 μM EGCG or EC and cultured for 24 h, 72 h and 120 h, respectively. Cell vitality was detected by CCK8 assay.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: Viruses. 2020 Feb 4;12(2):176. [Abstract]

One-step growth curve of PCV2 with EGCG treatment. PK-15 cells were inoculated with PCV2 at MOI = 1.0 and cultured with 100 μM EGCG or (-)-Epicatechin (EC) treatment. TCID50 at various time points were determined by IFA and calculated according to the Reed-Muench method.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: Viruses. 2020 Feb 4;12(2):176. [Abstract]

EGCG inhibited the infectivity of PCV2. PK-15 cells were inoculated with PCV2 at MOI=1.0 with EGCG or (-)-Epicatechin (EC, 10-100 μM) addition. The expression inhibition of PCV2 capsid protein was detected by immunoblotting at 72 hpi.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: Viruses. 2020 Feb 4;12(2):176. [Abstract]

EGCG inhibited the infectivity of PCV2. PK-15 cells were inoculated with PCV2 at MOI=1.0 with EGCG or (-)-Epicatechin (EC, 10-100 μM) addition. PCV2 genome copies were measured by real-time PCR.

(-)-Epicatechin purchased from MedChemExpress. Usage Cited in: Viruses. 2020 Feb 4;12(2):176. [Abstract]

EGCG inhibited the infectivity of PCV2. PK-15 cells were inoculated with PCV2 at MOI=1.0 with EGCG or (-)-Epicatechin (EC, 10-100 μM) addition. Indirect IFA detection of PCV2 infected cells.
J Food Meas Charact

2026 Jun 26.
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Rapid Commun Mass Spectrom

Chemical Profiling of Chixiaodou Danggui San Using Liquid Chromatography-Tandem Mass Spectrometry With Data Mining Strategy. [Abstract]

2025 Dec 15;39(23):e10134. PMID: 40907972
Biomed Chromatogr

Investigation Into the Chemical Constituents and Cytotoxic Effects on Lung Cancer Cells of the Rhizomes of Polygonum bistorta L. and Polygonum paleaceum Wall. [Abstract]

2025 Nov;39(11):e70225. PMID: 40984030
Patent

US20230014181.
Int J Insect Sci

Do Bioflavonoids in Juniperus virginiana Heartwood Stimulate Oviposition in the Ladybird Coleomegilla maculata?. [Abstract]

2018 Feb 28:10:1179543318758409. PMID: 29531477

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (344.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 2 mg/mL (6.89 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4451 mL

17.2253 mL

34.4507 mL

5 mM

0.6890 mL

3.4451 mL

6.8901 mL

10 mM

0.3445 mL

1.7225 mL

3.4451 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocole

All Molecular Biology Cell Biology Signal Pathway Related

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Pyroptosis Solutions
Pyroptosis is a lytic inflammatory cell-death pathway executed by gasdermin pores, most classically through inflammasome-mediated activation of caspase-1, cleavage of gasdermin D, membrane pore formation, LDH release, and secretion of IL-1β and IL-18. The canonical pathway is commonly modeled by priming cells with an inflammatory signal such as LPS to induce pro-IL-1β and inflammasome components, followed by an activation signal such as ATP or nigericin to activate NLRP3, ASC speck formation, caspase-1 cleavage, GSDMD cleavage, cytokine release, and pyroptotic membrane rupture. The non-canonical pathway is triggered when cytosolic LPS activates mouse caspase-11 or human caspase-4/5, leading to GSDMD cleavage and pyroptosis, and this can secondarily activate NLRP3-dependent IL-1β release. Pyroptosis is linked to inflammatory injury, infection, cancer, liver disease, ocular disease, placental inflammation, and other disease phenotypes, but unresolved questions include which gasdermin fam

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (286 KB)
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- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9. [Content Brief]

[2]. Shay J, et al. Molecular Mechanisms and Therapeutic Effects of (-)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration. Oxid Med Cell Longev. 2015;2015:181260. [Content Brief]

[3]. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15;589(Pt 18):4615-31. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.4451 mL	17.2253 mL	34.4507 mL	86.1267 mL
H₂O / DMSO	5 mM	0.6890 mL	3.4451 mL	6.8901 mL	17.2253 mL
DMSO	10 mM	0.3445 mL	1.7225 mL	3.4451 mL	8.6127 mL
	15 mM	0.2297 mL	1.1484 mL	2.2967 mL	5.7418 mL
	20 mM	0.1723 mL	0.8613 mL	1.7225 mL	4.3063 mL
	25 mM	0.1378 mL	0.6890 mL	1.3780 mL	3.4451 mL
	30 mM	0.1148 mL	0.5742 mL	1.1484 mL	2.8709 mL
	40 mM	0.0861 mL	0.4306 mL	0.8613 mL	2.1532 mL
	50 mM	0.0689 mL	0.3445 mL	0.6890 mL	1.7225 mL
	60 mM	0.0574 mL	0.2871 mL	0.5742 mL	1.4354 mL
	80 mM	0.0431 mL	0.2153 mL	0.4306 mL	1.0766 mL
	100 mM	0.0345 mL	0.1723 mL	0.3445 mL	0.8613 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

(-)-Epicatechin

17 Cited Publications

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(-)-Epicatechin

Publications Citing Use of MedChemExpress (MCE) (-)-Epicatechin

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