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  3. COX Autophagy Virus Protease
  4. (-)-Epicatechin gallate

(-)-Epicatechin gallate  (Synonyms: Epicatechin gallate; ECG; (-)-Epicatechin 3-O-gallate)

Cat. No.: HY-N0002 Purity: 98.39%
COA Handling Instructions

(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.

For research use only. We do not sell to patients.

(-)-Epicatechin gallate Chemical Structure

(-)-Epicatechin gallate Chemical Structure

CAS No. : 1257-08-5

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10 mM * 1 mL in DMSO USD 61 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of (-)-Epicatechin gallate:

(-)-Epicatechin gallate Related Antibodies

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  • Biological Activity

  • Protocol

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Description

(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.

IC50 & Target

COX-1

7.5 μM (IC50)

In Vitro

(-)-Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-Epicatechin gallate Related Antibodies
In Vivo

(-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

442.37

Appearance

Solid

Formula

C22H18O10
CAS No.
SMILES

O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (67.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2606 mL 11.3028 mL 22.6055 mL
5 mM 0.4521 mL 2.2606 mL 4.5211 mL
10 mM 0.2261 mL 1.1303 mL 2.2606 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.91 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.57%

COA (255 KB) HNMR (186 KB) LCMS (408 KB)

Handling Instructions (2659 KB)
References
Animal Administration

Rats[2]
Male Sprague-Dawley rats, obtained at 7 weeks of age (210-245 g) are used. Epicatechin gallate (ECG) is suspended in 0.5% w/v sodium carboxymethylcellulose at 12.5, 25.0 and 50.0 mg/10 mL for oral administration to rats at 10 mL/kg. For intravenous injection in rats at 1.0 mg/kg, an ethanolic solution of Epicatechin gallate is diluted with 10% w/v sodium citrate solution to 1.0 mg/mL; the final concentration of ethanol is 1% v/v[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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(-)-Epicatechin gallate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

(-)-Epicatechin gallate1257-08-5Epicatechin gallate ECG (-)-Epicatechin 3-O-gallateCOXAutophagyVirus ProteaseCyclooxygenaseInhibitorinhibitorinhibit

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