1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. DiMNF

DiMNF (Synonyms: 3',4'-Dimethoxy-αNF)

Cat. No.: HY-103222 Purity: 98.01%
Handling Instructions

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent.

For research use only. We do not sell to patients.

DiMNF Chemical Structure

DiMNF Chemical Structure

CAS No. : 14756-24-2

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].

In Vitro

DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1].
DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1].
DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Huh7 cell
Concentration: 10 μM
Incubation Time: 4 h or 1 h
Result: Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3.
Molecular Weight

332.35

Formula

C21H16O4

CAS No.
SMILES

O=C1C2=CC=C3C=CC=CC3=C2OC(C4=CC=C(OC)C(OC)=C4)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.61 mM; ultrasonic and warming and heat to 70°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0089 mL 15.0444 mL 30.0888 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL
10 mM 0.3009 mL 1.5044 mL 3.0089 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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DiMNF
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HY-103222
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