1. Immunology/Inflammation
  2. Aryl Hydrocarbon Receptor
  3. DiMNF

DiMNF  (Synonyms: 3',4'-Dimethoxy-αNF)

Cat. No.: HY-103222 Purity: 98.01%
COA Handling Instructions

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent.

For research use only. We do not sell to patients.

DiMNF Chemical Structure

DiMNF Chemical Structure

CAS No. : 14756-24-2

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
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Based on 1 publication(s) in Google Scholar

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Description

DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].

In Vitro

DiMNF (3',4'-Dimethoxy-αNF) (10 μM; 4 h) minimally influences AHR gene battery[1].
DiMNF (10 μM; 1 h) effectively suppresses cytokine-mediated inflammatory gene expression[1].
DiMNF adopts a unique orientation within the ligand binding pocket of AHR[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: Huh7 cell
Concentration: 10 μM
Incubation Time: 4 h or 1 h
Result: Decreased CYP1A1 mRNA expression (4 h). Exhibited repressive activity toward cytokine-mediated SAA1 induction (1 h). Significantly reduced IL1β-mediated mRNA induction of C4, C1S, C1R, and C3.
Molecular Weight

332.35

Formula

C21H16O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC=C3C=CC=CC3=C2OC(C4=CC=C(OC)C(OC)=C4)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (37.61 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0089 mL 15.0444 mL 30.0888 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0089 mL 15.0444 mL 30.0888 mL 75.2219 mL
5 mM 0.6018 mL 3.0089 mL 6.0178 mL 15.0444 mL
10 mM 0.3009 mL 1.5044 mL 3.0089 mL 7.5222 mL
15 mM 0.2006 mL 1.0030 mL 2.0059 mL 5.0148 mL
20 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7611 mL
25 mM 0.1204 mL 0.6018 mL 1.2036 mL 3.0089 mL
30 mM 0.1003 mL 0.5015 mL 1.0030 mL 2.5074 mL
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DiMNF Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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