1. Apoptosis
    Metabolic Enzyme/Protease
  2. Caspase
    5-Lipoxygenase
    Apoptosis
  3. Wedelolactone

Wedelolactone 

Cat. No.: HY-N0551
Handling Instructions

Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Anti-cancer, anti-inflammatory, and antioxidant activities.

For research use only. We do not sell to patients.

Wedelolactone Chemical Structure

Wedelolactone Chemical Structure

CAS No. : 524-12-9

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Description

Wedelolactone, a natural product from Ecliptae herba, suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex[1]. Wedelolactone inhibits 5-lipoxygenase (5-Lox) (IC50~2.5 μM) activity by an oxygen radical scavenging mechanism. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt[2]. Anti-cancer, anti-inflammatory, and antioxidant activities[3].

IC50 & Target[1][2][3]

Caspase-11

 

5-lipoxygenase

2.5 μM (IC50)

Apoptosis

 

Molecular Weight

314.25

Formula

C₁₆H₁₀O₇

CAS No.

524-12-9

SMILES

O=C1C2=C(OC3=CC(O)=C(O)C=C32)C4=C(O)C=C(OC)C=C4O1

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Wedelolactone
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