EGFR-IN-109
EGFR-IN-109 (compound 4) is an EGFR inhibitor, with the IC50 values of 25.8 and 182.3 nM for EGFRWT and EGFRT790M, respectively. EGFR-IN-109 arrests the cancer cells’ growth at the G2/M phase and induces both early and late apoptosis. EGFR-IN-109 can be used in cancer research.
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- CAS No.: 3019971-97-9
- Formule: C12H16N4OS
- Masse moléculaire:264.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
IC50 & Target
|
EGFR 25.8 nM (IC50) |
EGFRT790M 182.3 nM (IC50) |
Caspase-3 |
Caspase-9 |
Bax |
Bcl-2 |
In Vitro
EGFR-IN-109 (compound 4) (0-20 μM, 2 days) inhibits the proliferation of EGFR-expressing cells MCF-7 and A549, with IC50 values of 13.06 and 20.13 μM, respectively[1].
EGFR-IN-109 (13.06 μM, 24 h) promotes apoptosis of A549 cells by arresting the cell growth at the G2/M phase[1].
EGFR-IN-109 (13.06 μM, 72 h) promotes the protein expression of caspase-3, caspase-9 and BAX in A549 cells, and down-regulates the protein expression of Bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, A549, the normal cell lines W138 cell
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Concentration:0-20 μM
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Incubation Time:2 days
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Result:Showed obvious inhibitory effect on MCF-7 and A549, and weak inhibitory effect on WI-38 cell line, with the selectivity index of 2.8 and 1.8 for the two cancer cell lines, respectively.
Chemical Information
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CAS No. 3019971-97-9
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Masse moléculaire 264.35
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Formule C12H16N4OS
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SMILES
NNCC(NC1=O)=NC2=C1C3=C(S2)CC(C)CC3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-109 Related Classifications
HY-162360 Related Classifications
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