1. Apoptosis
  2. Bcl-2 Family


Cat. No.: HY-19725 Purity: 98.55%
Handling Instructions

A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.

For research use only. We do not sell to patients.
A-1155463 Chemical Structure

A-1155463 Chemical Structure

CAS No. : 1235034-55-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 248 In-stock
5 mg USD 168 In-stock
10 mg USD 252 In-stock
50 mg USD 840 In-stock
100 mg USD 1380 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell.

IC50 & Target

EC50: 70 nM (BCL-XL, Molt-4 cell)[1]

In Vitro

A-1155463 shows picomolar binding affinity to BCL-XL (Ki<0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki= 80 nM) and related proteins BCL-W (Ki= 19 nM) and MCL-1 (Ki> 440 nM) [2]. A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC50 values ≤0.5 μM in the presence of 10 % FBS[3].

In Vivo

A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses[2].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.4930 mL 7.4650 mL 14.9301 mL
5 mM 0.2986 mL 1.4930 mL 2.9860 mL
10 mM 0.1493 mL 0.7465 mL 1.4930 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Mice: Following a single 5 mg/kg IP dose of A-1155463 in nontumor bearing SCID-Beige mice, platelet counts fell dramatically as measured at 6 h postdose and then rebounded to normal levels within 72 h. A-1155463 is then administered to SCID-Beige mice that had been inoculated with BCL-XL-dependent H146 tumor cells with a daily dose at 5 mg/kg IP for 14 days[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.55%

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