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  3. AZD4320

AZD4320 

Cat. No.: HY-112416 Purity: 99.10% ee.: 99.75%
Handling Instructions

AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.

For research use only. We do not sell to patients.

AZD4320 Chemical Structure

AZD4320 Chemical Structure

CAS No. : 1357576-48-7

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Based on 1 publication(s) in Google Scholar

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Description

AZD4320 is a novel BH3-mimicking dual BCL2/BCLxL inhibitor with IC50s of 26 nM, 17 nM, and 170 nM for KPUM-MS3, KPUM-UH1, and STR-428 cells, respectively.

IC50 & Target

BCL2

17 nM (IC50, KPUM-UH1 cells)

BCLxL

17 nM (IC50, KPUM-UH1 cells)

In Vitro

AZD4320 potently augments the antitumor effect of AZD5153 (Cat. No.: HY-100653A) in double expressing lymphoma (DEL)- and double hit lymphoma (DHL)-derived cell lines in a dose-dependent manner. AZD4320 shows mostly synergistic, and at least additive, growth inhibitory effects on DEL- and DHL derived cell lines, and profoundly increases cells undergoing apoptosis in all three cell lines[1].

Molecular Weight

945.53

Formula

C₄₅H₄₈ClF₃N₄O₇S₃

CAS No.

1357576-48-7

SMILES

O=C(NS(=O)(C1=CC=C(N[[email protected]](CCN(CCO)C)CSC2=CC=CC=C2)C(S(=O)(C(F)(F)F)=O)=C1)=O)C3=CC=C(N4CCC([[email protected]](C5=CC=CC=C5C6=CC=C(Cl)C=C6)O)CC4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (132.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0576 mL 5.2880 mL 10.5761 mL
5 mM 0.2115 mL 1.0576 mL 2.1152 mL
10 mM 0.1058 mL 0.5288 mL 1.0576 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (6.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Two DEL-derived cell lines, KPUM-MS3 and KPUM-UH1, and a DHL-derived cell line, STR-428 are used. To examine the combinatory growth inhibitory effects of AZD4320, cells are treated with five concentrations (0.25, 0.5, 1.0, 2.0, 4.0×IC50) for 72 h, and subjected to a modified MTT assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.10% ee.: 99.75%

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Keywords:

AZD4320AZD 4320AZD-4320Bcl-2 FamilyInhibitorinhibitorinhibit

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Product Name:
AZD4320
Cat. No.:
HY-112416
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