Esomeprazole (Synonyms: (S)-Omeprazole; (-)-Omeprazole)

Name: Esomeprazole
Brand: MedChemExpress
SKU: HY-17021
Rating: 5.0 (3 reviews)

Cat. No.: HY-17021 Purity: 99.32%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H⁺, K⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research.

For research use only. We do not sell to patients.

Esomeprazole Chemical Structure

CAS No. : 119141-88-7

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Esomeprazole:

Esomeprazole magnesium trihydrate In-stock
(R)-Esomeprazole In-stock
Esomeprazole potassium salt In-stock
Esomeprazole sodium In-stock
Esomeprazole magnesium In-stock
Esomeprazole (Standard) In-stock
Esomeprazole-d₃ sodium Get quote
Esomeprazole-d₃ Get quote
Esomeprazole-d₃ potassium Get quote
Esomeprazole magnesium salt Get quote
Esomeprazole hemistrontium Get quote

3 Publications Citing Use of MCE Esomeprazole

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H⁺, K⁺-ATPase^[1]^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	GI₅₀	> 100 μM Compound: Esomeprazole	Cytotoxicity against HUVEC cells Cytotoxicity against HUVEC cells	[PMID: 31923859]
K562	GI₅₀	> 100 μM Compound: Esomeprazole	Antiproliferative activity against human K562 cells harboring MLL1 Antiproliferative activity against human K562 cells harboring MLL1	[PMID: 31923859]
L02	GI₅₀	> 100 μM Compound: Esomeprazole	Cytotoxicity against human L02 cells Cytotoxicity against human L02 cells	[PMID: 31923859]
MOLM-13	GI₅₀	32 μM Compound: Esomeprazole	Antiproliferative activity against human MOLM-13 cells harboring MLL1-AF9 Antiproliferative activity against human MOLM-13 cells harboring MLL1-AF9	[PMID: 31923859]
MV4-11	GI₅₀	47.6 μM Compound: Esomeprazole	Antiproliferative activity against human MV4-11 cells harboring MLL1-AF4 Antiproliferative activity against human MV4-11 cells harboring MLL1-AF4	[PMID: 31923859]

In Vitro

Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MDA-MB-468 cells
Concentration:	25 µM, 50 µM, 75 µM, 100 µM
Incubation Time:	20 hours
Result:	Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner.

In Vivo

Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury^[2]
Dosage:	30 mg/kg, 300 mg/kg
Administration:	Oral gavage; daily; for 19 or 11 days
Result:	Significantly inhibited the progression of fibrosis throughout the lungs of the animals.

Molecular Weight

345.42

Formula

C₁₇H₁₉N₃O₃S

CAS No.

119141-88-7

Appearance

Solid

Color

White to light brown

SMILES

O=[S@](C1=NC2=CC=C(OC)C=C2N1)CC3=NC=C(C)C(OC)=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (289.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8950 mL	14.4751 mL	28.9503 mL
5 mM	0.5790 mL	2.8950 mL	5.7901 mL
10 mM	0.2895 mL	1.4475 mL	2.8950 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.46%

Select Batch:

Data Sheet (274 KB) SDS (394 KB)

COA (247 KB) HNMR (434 KB) RP-HPLC (204 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3):439-46. [Content Brief]

[2]. Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16. [Content Brief]

[3]. Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8950 mL	14.4751 mL	28.9503 mL	72.3757 mL
	5 mM	0.5790 mL	2.8950 mL	5.7901 mL	14.4751 mL
	10 mM	0.2895 mL	1.4475 mL	2.8950 mL	7.2376 mL
	15 mM	0.1930 mL	0.9650 mL	1.9300 mL	4.8250 mL
	20 mM	0.1448 mL	0.7238 mL	1.4475 mL	3.6188 mL
	25 mM	0.1158 mL	0.5790 mL	1.1580 mL	2.8950 mL
	30 mM	0.0965 mL	0.4825 mL	0.9650 mL	2.4125 mL
	40 mM	0.0724 mL	0.3619 mL	0.7238 mL	1.8094 mL
	50 mM	0.0579 mL	0.2895 mL	0.5790 mL	1.4475 mL
	60 mM	0.0483 mL	0.2413 mL	0.4825 mL	1.2063 mL
	80 mM	0.0362 mL	0.1809 mL	0.3619 mL	0.9047 mL
	100 mM	0.0290 mL	0.1448 mL	0.2895 mL	0.7238 mL

Esomeprazole Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Esomeprazole119141-88-7(S)-Omeprazole (-)-OmeprazoleProton PumpBacterialCYP3A4H+K+-ATPaseantacidanti-inflammationfibrosisgastroesophagealInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Esomeprazole (Synonyms: (S)-Omeprazole; (-)-Omeprazole)

Customer Review

Other Forms of Esomeprazole:

Esomeprazole Related Antibodies

3 Publications Citing Use of MCE Esomeprazole

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Esomeprazole Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Esomeprazole Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report