1. Membrane Transporter/Ion Channel
  2. Proton Pump

Esomeprazole magnesium (Synonyms: (S)-Omeprazole magnesium; (-)-Omeprazole magnesium)

Cat. No.: HY-B1446 Purity: >98.0%
Handling Instructions

Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.

For research use only. We do not sell to patients.

Esomeprazole magnesium Chemical Structure

Esomeprazole magnesium Chemical Structure

CAS No. : 161973-10-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Esomeprazole magnesium is an inhibitor of H+, K+-ATPase, effectively used in the research of upper intestinal disorder.

IC50 & Target

H+, K+-ATPase[1]

In Vitro

Esomeprazole magnesium is an inhibitor of H+, K+-ATPase[1].

In Vivo

Esomeprazole magnesium (0.5, 5, 50 mg/kg/day, p.o.) produces increased gastric total antioxidant capacity, decreases gastric lipid peroxide levels, significantly increases superoxide dismutase levels, but shows no obvious effect on colonic lipid peroxide levels in mice[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (175.29 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4023 mL 7.0114 mL 14.0229 mL
5 mM 0.2805 mL 1.4023 mL 2.8046 mL
10 mM 0.1402 mL 0.7011 mL 1.4023 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (2.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.92 mM); Clear solution

References
Animal Administration
[1]

Mice[1]
In this 10-day supplementation experiment, mice (n = 10/group) receive the following: 1) as a control group, only the vehicle for dissolution of Esomeprazole (PEG-400) given orally once daily by gastric gavage; 2) Esomeprazole 0.5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; 3) Esomeprazole 5 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage; and 4) Esomeprazole 50 mg/kg in an equivalent volume of PEG-400 given orally once daily by gastric lavage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

713.12

Formula

C₃₄H₃₆MgN₆O₆S₂

CAS No.

161973-10-0

SMILES

CC1=C(N=CC(C)=C1OC)CS2=O[Mg+2]3([N](C4=CC=C(OC)C=C4[N-]5)=C5S(CC(N=CC(C)=C6OC)=C6C)=O3)[N]7=C2[N-]C8=CC(OC)=CC=C78

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Esomeprazole magnesium
Cat. No.:
HY-B1446
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Esomeprazole magnesium

Cat. No.: HY-B1446