2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. Esomeprazole magnesium trihydrate

Esomeprazole magnesium trihydrate  (Synonyms: (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate)

Cat. No.: HY-17022 Purity: 95.79%
COA Handling Instructions

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases.

For research use only. We do not sell to patients.

Esomeprazole magnesium trihydrate Chemical Structure

Esomeprazole magnesium trihydrate Chemical Structure

CAS No. : 217087-09-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Esomeprazole magnesium trihydrate:

Esomeprazole magnesium trihydrate Related Antibodies

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  • Purity & Documentation

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Description

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research[1][2]. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases[4].

IC50 & Target

H+, K+-ATPase[1]
In Vitro

Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Esomeprazole magnesium trihydrate Related Antibodies
In Vivo

Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A/J mice[1]
Dosage: 0.5 mg/kg, 5 mg/kg, 50 mg/kg
Administration: Oral gavage; daily; for 10 days
Result: Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.
Clinical Trial
Molecular Weight

767.17

Appearance

Solid

Formula

C34H42MgN6O9S2
CAS No.
SMILES

[H]O[H].[H]O[H].[H]O[H].COC1=CC=C2[N]3=C([N-]C2=C1)[S](CC(N=CC(C)=C4OC)=C4C)=[O][Mg+2]35[N](C6=CC=C7OC)=C([N-]C6=C7)[S](CC(N=CC(C)=C8OC)=C8C)=[O]5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (65.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3035 mL 6.5175 mL 13.0349 mL
5 mM 0.2607 mL 1.3035 mL 2.6070 mL
10 mM 0.1303 mL 0.6517 mL 1.3035 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Esomeprazole magnesium trihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Esomeprazole magnesium217087-09-7(S)-Omeprazole magnesium(-)-Omeprazole magnesiumProton PumpH+K+-ATPaseantioxidantCu/Zn-superoxideintestinaldisordersInhibitorinhibitorinhibit

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