1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Esomeprazole magnesium trihydrate

Esomeprazole magnesium trihydrate (Synonyms: (S)-Omeprazole magnesium trihydrate; (-)-Omeprazole magnesium trihydrate)

Cat. No.: HY-17022 Purity: ≥95.0%
Handling Instructions

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases.

For research use only. We do not sell to patients.

Esomeprazole magnesium trihydrate Chemical Structure

Esomeprazole magnesium trihydrate Chemical Structure

CAS No. : 217087-09-7

Size Price Stock Quantity
50 mg USD 156 In-stock
Estimated Time of Arrival: December 31
100 mg USD 264 In-stock
Estimated Time of Arrival: December 31
200 mg USD 360 In-stock
Estimated Time of Arrival: December 31
500 mg USD 798 In-stock
Estimated Time of Arrival: December 31
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Description

Esomeprazole magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research[1][2]. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases[4].

IC50 & Target

H+, K+-ATPase[1]

In Vitro

Esomeprazole magnesium trihydrate is develped from Esomeprazole strontium tetrahydrate (EST). EST contains esomeprazole, the S-enantiomer of omeprazole a salt-exchanged version of Esomeprazole magnesium trihydrate[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Esomeprazole magnesium (0.5-50 mg/kg; oral gavage; daily; for 10 days; A/J mice) treatment increases gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A/J mice[1]
Dosage: 0.5 mg/kg, 5 mg/kg, 50 mg/kg
Administration: Oral gavage; daily; for 10 days
Result: Gastric total antioxidant capacity and Cu/Zn-superoxide dismutase activity are increased.
Clinical Trial
Molecular Weight

767.17

Formula

C₃₄H₄₂MgN₆O₉S₂

CAS No.
SMILES

[H]O[H].[H]O[H].[H]O[H].COC1=CC=C2[N]3=C([N-]C2=C1)[S](CC(N=CC(C)=C4OC)=C4C)=[O][Mg+2]35[N](C6=CC=C7OC)=C([N-]C6=C7)[S](CC(N=CC(C)=C8OC)=C8C)=[O]5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (65.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3035 mL 6.5175 mL 13.0349 mL
5 mM 0.2607 mL 1.3035 mL 2.6070 mL
10 mM 0.1303 mL 0.6517 mL 1.3035 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (6.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Esomeprazole magnesium(S)-Omeprazole magnesium(-)-Omeprazole magnesiumProton PumpH+K+-ATPaseantioxidantCu/Zn-superoxideintestinaldisordersInhibitorinhibitorinhibit

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Esomeprazole magnesium trihydrate
Cat. No.:
HY-17022
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