1. Membrane Transporter/Ion Channel
  2. Proton Pump
  3. Esomeprazole sodium

Esomeprazole sodium (Synonyms: (S)-Omeprazole sodium)

Cat. No.: HY-17023 Purity: >98.0%
Handling Instructions

Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.

For research use only. We do not sell to patients.

Esomeprazole sodium Chemical Structure

Esomeprazole sodium Chemical Structure

CAS No. : 161796-78-7

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Description

Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. IC50 value: Target: proton pump Esomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

Clinical Trial
Molecular Weight

367.40

Formula

C₁₇H₁₈N₃NaO₃S

CAS No.

161796-78-7

SMILES

O=[[email protected]](C1=NC2=CC(OC)=CC=C2N1[Na])CC3=NC=C(C)C(OC)=C3C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (680.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7218 mL 13.6091 mL 27.2183 mL
5 mM 0.5444 mL 2.7218 mL 5.4437 mL
10 mM 0.2722 mL 1.3609 mL 2.7218 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Esomeprazole(S)-OmeprazoleProton PumpInhibitorinhibitorinhibit

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Product name:
Esomeprazole sodium
Cat. No.:
HY-17023
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