1. Membrane Transporter/Ion Channel
    Autophagy
    Apoptosis
  2. Proton Pump
    Autophagy
    Apoptosis
  3. Pantoprazole

Pantoprazole (Synonyms: BY1023; SKF96022)

Cat. No.: HY-17507
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Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142).

For research use only. We do not sell to patients.

Pantoprazole Chemical Structure

Pantoprazole Chemical Structure

CAS No. : 102625-70-7

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Description

Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

IC50 & Target

proton pump

In Vitro

Pantoprazole (BY1023; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells[1].
Pantoprazole (BY10232) can block exosome release. Pantoprazole (BY10232) inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pantoprazole (BY1023; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1].
Pantoprazole (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing MCF-7 or A431 xenografts[1]
Dosage: 200 mg/kg
Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.
Significantly increased tumor growth delay with a single dose with Doxorubicin.
There is no effect on growth delay alone.
Clinical Trial
Molecular Weight

383.37

Formula

C₁₆H₁₅F₂N₃O₄S

CAS No.
SMILES

O=S(C1=NC2=CC=C(OC(F)F)C=C2N1)CC3=NC=CC(OC)=C3OC

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Keywords:

PantoprazoleBY1023 SKF96022BY 1023BY-1023SKF96022SKF 96022SKF-96022Proton PumpAutophagyApoptosisorallyPPIexosomereleaseH+/K+-ATPasepHstabilityanti-secretoryanti-ulcerDoxorubicinMCF-7A431Inhibitorinhibitorinhibit

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Pantoprazole
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