1. Membrane Transporter/Ion Channel
    Autophagy
    Apoptosis
  2. Proton Pump
    Autophagy
    Apoptosis
  3. Pantoprazole sodium hydrate

Pantoprazole sodium hydrate (Synonyms: BY1023 sodium hydrate; SKF96022 sodium hydrate)

Cat. No.: HY-17507B Purity: 99.94%
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Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142).

For research use only. We do not sell to patients.

Pantoprazole sodium hydrate Chemical Structure

Pantoprazole sodium hydrate Chemical Structure

CAS No. : 164579-32-2

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Solution
10 mM * 1 mL USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].

In Vitro

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells[1].
Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin[1].
Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing MCF-7 or A431 xenografts[1]
Dosage: 200 mg/kg
Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i.v.)
Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination.
Significantly increased tumor growth delay with a single dose with Doxorubicin.
There is no effect on growth delay alone.
Clinical Trial
Molecular Weight

432.37

Formula

C₁₆H₁₇F₂N₃NaO₅.₅S

CAS No.
SMILES

O=S(C1=NC2=CC=C(OC(F)F)C=C2N1[Na])CC3=NC=CC(OC)=C3OC.[1.5H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

Pantoprazole sodiumBY1023 sodiumSKF96022 sodiumProton PumpAutophagyApoptosisorallyPPIexosomereleaseH+/K+-ATPasepHstabilityanti-secretoryanti-ulcerDoxorubicinMCF-7A431Inhibitorinhibitorinhibit

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Pantoprazole sodium hydrate
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