1. Neuronal Signaling
  2. Serotonin Transporter
  3. Escitalopram

Escitalopram (Synonyms: (S)-Citalopram; (S)-(+)-Citalopram)

Cat. No.: HY-14258
Handling Instructions

Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression.

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Escitalopram Chemical Structure

Escitalopram Chemical Structure

CAS No. : 128196-01-0

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Description

Escitalopram ((S)-Citalopram), the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram is an antidepressant for the research of major depression[1][2].

IC50 & Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)[1]

In Vivo

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively [4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[3]
Dosage: 10 mg/kg
Administration: I.p.; daily for 28 days
Result: Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.
Animal Model: APP-PS1 hemizygous female mice (4 months of age)[4]
Dosage: 2.5-5 mg/kg
Administration: Daily; drinking water for a total of 4 months
Result: At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.
Clinical Trial
Molecular Weight

324.39

Formula

C₂₀H₂₁FN₂O

CAS No.

128196-01-0

SMILES

FC1=CC=C([[email protected]@]2(CCCN(C)C)C(C=CC(C#N)=C3)=C3CO2)C=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Escitalopram(S)-Citalopram (S)-(+)-CitalopramSerotonin Transporter5-HTTSERTSLC6A4S-enantiomerreuptakeselectivityantidepressantdepressioncognitiveimpairmentsInhibitorinhibitorinhibit

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Escitalopram
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