1. Neuronal Signaling
  2. Serotonin Transporter
  3. Escitalopram oxalate

Escitalopram oxalate (Synonyms: (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate)

Cat. No.: HY-14258A Purity: 99.98%
Handling Instructions

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression.

For research use only. We do not sell to patients.

Escitalopram oxalate Chemical Structure

Escitalopram oxalate Chemical Structure

CAS No. : 219861-08-2

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

IC50 & Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)[1]

In Vivo

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively [4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[3]
Dosage: 10 mg/kg
Administration: I.p.; daily for 28 days
Result: Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.
Animal Model: APP-PS1 hemizygous female mice (4 months of age)[4]
Dosage: 2.5-5 mg/kg
Administration: Daily; drinking water for a total of 4 months
Result: At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.
Clinical Trial
Molecular Weight

414.43

Formula

C₂₂H₂₃FN₂O₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 14.29 mg/mL (34.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4130 mL 12.0648 mL 24.1295 mL
5 mM 0.4826 mL 2.4130 mL 4.8259 mL
10 mM 0.2413 mL 1.2065 mL 2.4130 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Escitalopram oxalate
Cat. No.:
HY-14258A
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