Cyclo(L-leucyl-L-tryptophyl) (Synonyms: Cyclo(Leu-Trp))

Cat. No.: HY-P2092 Purity: 99.90%: Data Sheet
COA

SDS
Handling Instructions
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Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclo(L-leucyl-L-tryptophyl) Chemical Structure

CAS No. : 15136-34-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	>100 μM Compound: 3a, cyclo-L-Trp-L-Leu	Cytotoxicity against human cisplatin resistant A2780 cells after 72 hrs by MTT assay Cytotoxicity against human cisplatin resistant A2780 cells after 72 hrs by MTT assay	[PMID: 22617493]
A2780	IC₅₀	>100 μM Compound: 3a, cyclo-L-Trp-L-Leu	Cytotoxicity against human cisplatin sensitive A2780 cells after 72 hrs by MTT assay Cytotoxicity against human cisplatin sensitive A2780 cells after 72 hrs by MTT assay	[PMID: 22617493]
BV-2	IC₅₀	>20 μM Compound: 13	Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay	[PMID: 39140432]
K562	IC₅₀	>100 μM Compound: 3a, cyclo-L-Trp-L-Leu	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 22617493]

Molecular Weight

299.37

Formula

C₁₇H₂₁N₃O₂

CAS No.

15136-34-2

Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Leu-Trp)

Sequence Shortening

Cyclo(LW)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (334.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3403 mL	16.7017 mL	33.4035 mL
5 mM	0.6681 mL	3.3403 mL	6.6807 mL
10 mM	0.3340 mL	1.6702 mL	3.3403 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB) HNMR (199 KB) RP-HPLC (110 KB)

Handling Instructions (2659 KB)

References

[1]. Kumar SN, et al. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. Peptides. 2014 Mar;53:48-58. [Content Brief]

[2]. Zubare-Samuelov M, et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1255-62. [Content Brief]

[3]. Shiba T, et al. Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor. Biopolymers. 1981 Sep;20(9):1985-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3403 mL	16.7017 mL	33.4035 mL	83.5087 mL
	5 mM	0.6681 mL	3.3403 mL	6.6807 mL	16.7017 mL
	10 mM	0.3340 mL	1.6702 mL	3.3403 mL	8.3509 mL
	15 mM	0.2227 mL	1.1134 mL	2.2269 mL	5.5672 mL
	20 mM	0.1670 mL	0.8351 mL	1.6702 mL	4.1754 mL
	25 mM	0.1336 mL	0.6681 mL	1.3361 mL	3.3403 mL
	30 mM	0.1113 mL	0.5567 mL	1.1134 mL	2.7836 mL
	40 mM	0.0835 mL	0.4175 mL	0.8351 mL	2.0877 mL
	50 mM	0.0668 mL	0.3340 mL	0.6681 mL	1.6702 mL
	60 mM	0.0557 mL	0.2784 mL	0.5567 mL	1.3918 mL
	80 mM	0.0418 mL	0.2088 mL	0.4175 mL	1.0439 mL
	100 mM	0.0334 mL	0.1670 mL	0.3340 mL	0.8351 mL

Cyclo(L-leucyl-L-tryptophyl) Related Classifications

Neurological Disease Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(L-leucyl-L-tryptophyl)15136-34-2Cyclo(Leu-Trp)BacterialFungalMelatonin Receptorcyclic dipeptidebacteriafungimelatonin receptorbitter ligandInhibitorinhibitorinhibit

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Cyclo(L-leucyl-L-tryptophyl) (Synonyms: Cyclo(Leu-Trp))

Cyclo(L-leucyl-L-tryptophyl) Related Antibodies

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•Related Small Molecules:

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Biological Activity

Purity & Documentation

References

Customer Review

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