Cyclo(L-leucyl-L-tryptophyl)
Based on 1 Customer Validation
Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 15136-34-2
- Formula: C17H21N3O2
- Molecular Weight:299.37
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>100 μM
Compound: 3a, cyclo-L-Trp-L-Leu
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Cytotoxicity against human cisplatin resistant A2780 cells after 72 hrs by MTT assay
Cytotoxicity against human cisplatin resistant A2780 cells after 72 hrs by MTT assay
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[PMID: 22617493] |
| A2780 | IC50 |
>100 μM
Compound: 3a, cyclo-L-Trp-L-Leu
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Cytotoxicity against human cisplatin sensitive A2780 cells after 72 hrs by MTT assay
Cytotoxicity against human cisplatin sensitive A2780 cells after 72 hrs by MTT assay
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[PMID: 22617493] |
| BV-2 | IC50 |
>20 μM
Compound: 13
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Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay
Antineuroinflammatory activity in LPS induced mouse BV-2 cells assessed as inhibition of NO production pretreated for 3 hrs followed by LPS addition and measured after 21 hrs by griess reagent based assay
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[PMID: 39140432] |
| K562 | IC50 |
>100 μM
Compound: 3a, cyclo-L-Trp-L-Leu
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Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
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[PMID: 22617493] |
Chemical Information
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CAS No. 15136-34-2
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Appearance Solid
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Molecular Weight 299.37
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Formula C17H21N3O2
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Color White to off-white
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Synonyms
Cyclo(Leu-Trp)
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Sequence
Cyclo(Leu-Trp)
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Sequence Shortening
Cyclo(LW)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (334.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Kumar SN, et al. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria. Peptides. 2014 Mar;53:48-58. [Content Brief]
[2]. Zubare-Samuelov M, et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. Am J Physiol Cell Physiol. 2003 Nov;285(5):C1255-62. [Content Brief]
[3]. Shiba T, et al. Some aspects of the relationship between the structure of a bitter diketopiperazine and its receptor. Biopolymers. 1981 Sep;20(9):1985-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3403 mL | 16.7017 mL | 33.4035 mL | 83.5087 mL |
| 5 mM | 0.6681 mL | 3.3403 mL | 6.6807 mL | 16.7017 mL | |
| 10 mM | 0.3340 mL | 1.6702 mL | 3.3403 mL | 8.3509 mL | |
| 15 mM | 0.2227 mL | 1.1134 mL | 2.2269 mL | 5.5672 mL | |
| 20 mM | 0.1670 mL | 0.8351 mL | 1.6702 mL | 4.1754 mL | |
| 25 mM | 0.1336 mL | 0.6681 mL | 1.3361 mL | 3.3403 mL | |
| 30 mM | 0.1113 mL | 0.5567 mL | 1.1134 mL | 2.7836 mL | |
| 40 mM | 0.0835 mL | 0.4175 mL | 0.8351 mL | 2.0877 mL | |
| 50 mM | 0.0668 mL | 0.3340 mL | 0.6681 mL | 1.6702 mL | |
| 60 mM | 0.0557 mL | 0.2784 mL | 0.5567 mL | 1.3918 mL | |
| 80 mM | 0.0418 mL | 0.2088 mL | 0.4175 mL | 1.0439 mL | |
| 100 mM | 0.0334 mL | 0.1670 mL | 0.3340 mL | 0.8351 mL |
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