1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. AZ9482

AZ9482 

Cat. No.: HY-119653 Purity: 98.17%
Handling Instructions

AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively.

For research use only. We do not sell to patients.

AZ9482 Chemical Structure

AZ9482 Chemical Structure

CAS No. : 1825345-33-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 159 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 260 In-stock
Estimated Time of Arrival: December 31
25 mg USD 500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively[1].

In Vitro

AZ9482 exhibits an EC50 of 24 nM in MDA-MB-468 cells[1].
AZ0108 treatment prevents CHK1 MARylation and induces hyperphosphorylation of CHK1, contributing to MPS formation and dysregulation of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-468 cells.
Concentration: 0-10 μM.
Incubation Time: 3 days.
Result: EC50 was 24 nM.
In Vivo

AZ0108 also displays toxicity in vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

450.49

Formula

C₂₆H₂₂N₆O₂

CAS No.

1825345-33-2

SMILES

O=C1NN=C(C2=CC=CC=C21)CC3=CC=CC(C(N4CCN(CC4)C5=NC=CC=C5C#N)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (277.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2198 mL 11.0990 mL 22.1981 mL
5 mM 0.4440 mL 2.2198 mL 4.4396 mL
10 mM 0.2220 mL 1.1099 mL 2.2198 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (4.62 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.62 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AZ9482AZ 9482AZ-9482PARPpoly ADP ribose polymeraseMDA-MB-468breastcancerInhibitorinhibitorinhibit

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AZ9482
Cat. No.:
HY-119653
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