1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. EB-47 dihydrochloride

EB-47 dihydrochloride 

Cat. No.: HY-108631 Purity: 99.72%
Handling Instructions

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.

For research use only. We do not sell to patients.

EB-47 dihydrochloride Chemical Structure

EB-47 dihydrochloride Chemical Structure

CAS No. : 1190332-25-2

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Description

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1].

In Vitro

EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0 µM, respectively[1].

In Vivo

EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].

Molecular Weight

610.45

Formula

C₂₄H₂₉Cl₂N₉O₆

CAS No.

1190332-25-2

SMILES

O=C1NCC2=C(C=CC=C21)NC(CN3CCN(CC3)C([[email protected]]4O[[email protected]]([[email protected]@H]([[email protected]@H]4O)O)N5C6=C(N=C5)C(N)=NC=N6)=O)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

EB-47EB47EB 47PARPpoly ADP ribose polymerasePARP-1ARTD-1cardiacreperfusionNADcerebralarterialocclusionARTD5ARTD6Inhibitorinhibitorinhibit

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EB-47 dihydrochloride
Cat. No.:
HY-108631
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