1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. EB-47 dihydrochloride

EB-47 dihydrochloride 

Cat. No.: HY-108631 Purity: 99.72%
Handling Instructions

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.

For research use only. We do not sell to patients.

EB-47 dihydrochloride Chemical Structure

EB-47 dihydrochloride Chemical Structure

CAS No. : 1190332-25-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 201 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 780 In-stock
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100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1].

In Vitro

EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

610.45

Formula

C₂₄H₂₉Cl₂N₉O₆

CAS No.

1190332-25-2

SMILES

O=C1NCC2=C(C=CC=C21)NC(CN3CCN(CC3)C([[email protected]]4O[[email protected]]([[email protected]@H]([[email protected]@H]4O)O)N5C6=C(N=C5)C(N)=NC=N6)=O)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (102.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6381 mL 8.1907 mL 16.3814 mL
5 mM 0.3276 mL 1.6381 mL 3.2763 mL
10 mM 0.1638 mL 0.8191 mL 1.6381 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

EB-47EB47EB 47PARPpoly ADP ribose polymerasePARP-1ARTD-1cardiacreperfusionNADcerebralarterialocclusionARTD5ARTD6Inhibitorinhibitorinhibit

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Product Name:
EB-47 dihydrochloride
Cat. No.:
HY-108631
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