1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. EB-47

EB-47 

Cat. No.: HY-15046
Handling Instructions

EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.

For research use only. We do not sell to patients.

EB-47 Chemical Structure

EB-47 Chemical Structure

CAS No. : 366454-36-6

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite[1].

IC50 & Target[1]

ARTD1/PARP1

45 nM (IC50)

In Vitro

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0 µM, respectively[1].

In Vivo

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation[3].

Molecular Weight

537.53

Formula

C₂₄H₂₇N₉O₆

CAS No.

366454-36-6

SMILES

O=C1NCC2=C(C=CC=C21)NC(CN3CCN(CC3)C([[email protected]]4O[[email protected]]([[email protected]@H]([[email protected]@H]4O)O)N5C6=C(N=C5)C(N)=NC=N6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

EB-47EB47EB 47PARPpoly ADP ribose polymerasePARP-1ARTD-1cardiacreperfusionNAD cerebralarterialocclusionARTD5ARTD6Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
EB-47
Cat. No.:
HY-15046
Quantity:
MCE Japan Authorized Agent: