2. Immunology/Inflammation Stem Cell/Wnt MAPK/ERK Pathway JAK/STAT Signaling Cell Cycle/DNA Damage Cytoskeleton
  3. Interleukin Related ERK STAT CDK Cadherin
  4. Anti-IL11 Antibody (X203)

Anti-IL11 Antibody (X203)  (Synonyms: EnX203)

Cat. No.: HY-P991218 Purity: 98.53%
COA
SDS
Technical Support

Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

Anti-IL11 Antibody (X203)

Anti-IL11 Antibody (X203) Chemical Structure

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Anti-IL11 Antibody (X203):

Anti-IL11 Antibody (X203) Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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ERK ERK1 ERK2 ERK5 ERK8

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STAT3 STAT5 STAT6 STAT1

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • Biological Activity

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  • Customer Review

Description

Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11[1][2]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target[1][2]

CDK1

 

ERK

 

STAT3

 

IL-11

 

E-cadherin

 

In Vitro

Anti-IL11 Antibody (X203) (20 μM; 48 h) effectively inhibits IL11-induced downstream STAT3 phosphorylation in Bleomycin (HY-17565A)-induced mouse nucleus pulposus (NP) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-IL11 Antibody (X203) Related Antibodies

Western Blot Analysis[1]

Cell Line: Mouse nucleus pulposus (NP) cells treated with Bleomycin (40 μg/mL)
Concentration: 20 μM
Incubation Time: 48 h
Result: Effectively inhibited IL11–induced downstream STAT3 phosphorylation
In Vivo

Anti-IL11 Antibody (X203) (20 mg/kg, i.p., twice a week for 2.5 weeks starting from 6 weeks of age) improves renal function and increases lifespan in a mouse model of Alport syndrome (AS)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type mice injected with BLM[1]
Dosage: 20 mg/kg
Administration: i.p., alternate days from day 7 to 21 after BLM
Result: Showed no effect on overall survival.
Greatly reduced lung hydroxyproline content.
Reduced the expression of ECM-related genes.
Increased Mmp2/Timp1 ratio (a signature of preferential ECM remodeling) compared to control.
Markedly reduced ERK and SMAD activation whereas STAT3 phosphorylation remained elevated.
Animal Model: Wild-type mice injected with BLM[1]
Dosage: 20 mg/kg
Administration: i.p., alternate days from day 14 to 28 after BLM
Result: Significantly reduced collagen deposition and parenchymal disruption, lung weights, and lung hydroxyproline content.
Had no effect on survival as compared to IgG treatment.
Reduced the expression of ECM proteins COL3A1 and fibronectin, as well as IL-11 levels in the lungs 28 days after BLM.
Markedly reduced ERK and SMAD activation whereas STAT3 phosphorylation remained elevated.
Animal Model: Col4a3-/- mice[2]
Dosage: 20 mg/kg
Administration: i.p., twice a week for 2.5 weeks starting from 6 weeks of age
Result: Attenuated total body weight loss compared with the IgG group.
Significantly reduced kidney fibrosis.
Reduced renal ERK and STAT3 activation, fibrosis, and a signature of epithelial-to-mesenchymal transition.
Reduced SNA1 expression, central to EMT/pEMT, and restored E-cadherin levels while preserving podocyte numbers and expression of podocyte-specific proteins.
Induced substantial upregulation of renal cyclin D1 and PCNA expression associated with SNAI1 inhibition.
Prolonged lifespan in mice.
Gene ID

3589  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

145.96 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-IL11 Antibody (X203)]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.53%

SDS (251 KB)

COA (232 KB) SDS-PAGE (129 KB) SEC-HPLC (117 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Anti-IL11 Antibody (X203) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-IL11 Antibody (X203)EnX203EnX 203EnX-203Interleukin RelatedERKSTATCDKCadherinILExtracellular signal regulated kinasesCyclin dependent kinasemouse lung fibroblastspulmonary fibrosisAlport syndromeInhibitorinhibitorinhibit

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