Anti-IL11 Antibody (X203)
Based on 2 publication(s) in Google Scholar
Anti-IL11 Antibody (X203) (EnX203) is a human-derived IgG1, κ type antibody inhibitor, targeting to human IL-11. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
For research use only. We do not sell to patients.
- Purity: 98.53%
- Molecular Weight:145.96 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-IL11 Antibody (X203)
More
Biological Activity
Human IgG1 kappa
Human
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CDK1 |
ERK |
STAT3 |
IL-11 |
E-cadherin |
Anti-IL11 Antibody (X203) (20 μM; 48 h) effectively inhibits IL11-induced downstream STAT3 phosphorylation in Bleomycin (HY-17565A)-induced mouse nucleus pulposus (NP) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse nucleus pulposus (NP) cells treated with Bleomycin (40 μg/mL)
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Concentration:20 μM
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Incubation Time:48 h
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Result:Effectively inhibited IL11–induced downstream STAT3 phosphorylation
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type mice injected with BLM[1]
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Dosage:20 mg/kg
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Administration:i.p., alternate days from day 7 to 21 after BLM
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Result:Showed no effect on overall survival.
Greatly reduced lung hydroxyproline content.
Reduced the expression of ECM-related genes.
Increased Mmp2/Timp1 ratio (a signature of preferential ECM remodeling) compared to control.
Markedly reduced ERK and SMAD activation whereas STAT3 phosphorylation remained elevated.
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Animal Model:Wild-type mice injected with BLM[1]
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Dosage:20 mg/kg
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Administration:i.p., alternate days from day 14 to 28 after BLM
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Result:Significantly reduced collagen deposition and parenchymal disruption, lung weights, and lung hydroxyproline content.
Had no effect on survival as compared to IgG treatment.
Reduced the expression of ECM proteins COL3A1 and fibronectin, as well as IL-11 levels in the lungs 28 days after BLM.
Markedly reduced ERK and SMAD activation whereas STAT3 phosphorylation remained elevated.
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Animal Model:Col4a3-/- mice[2]
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Dosage:20 mg/kg
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Administration:i.p., twice a week for 2.5 weeks starting from 6 weeks of age
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Result:Attenuated total body weight loss compared with the IgG group.
Significantly reduced kidney fibrosis.
Reduced renal ERK and STAT3 activation, fibrosis, and a signature of epithelial-to-mesenchymal transition.
Reduced SNA1 expression, central to EMT/pEMT, and restored E-cadherin levels while preserving podocyte numbers and expression of podocyte-specific proteins.
Induced substantial upregulation of renal cyclin D1 and PCNA expression associated with SNAI1 inhibition.
Prolonged lifespan in mice.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 145.96 kDa
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Color Colorless to light yellow
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SMILES
[Anti-IL11 Antibody (X203)]
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Synonyms
EnX203
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis. [Abstract]2025 Sep 1:165:115450. PMID: 40897114 -
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Chen R, et al. Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis. Int Immunopharmacol. 2025 Nov 14;165:115450. [Content Brief]
[2]. Widjaja AA, et al. A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. J Am Soc Nephrol. 2022 Apr;33(4):718-730. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-IL11 Antibody (X203) Related Classifications
HY-P991218 Related Classifications
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