BI-765423
Based on 1 Customer Validation
BI-765423 is a selective monoclonal antibody inhibitor targeting IL-11. BI-765423 blocks IL-11-mediated signaling, inhibits fibroblast activation, and can extend the healthy lifespan of mammals, counteract cellular senescence in human cells, and alleviate inflammatory aging-related pathological processes. BI-765423 is primarily used in research on fibrotic diseases such as idiopathic pulmonary fibrosis (IPF).
For research use only. We do not sell to patients.
- Purity: 95.52%
- Molecular Weight:146.61 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
IL-11
In in vitro experiments using human fibroblasts, BI-765423 significantly inhibits fibroblast activation and reduced the progression of inflammation- and senescence-related pathological processes[1][2].
In in vitro cellular senescence transformation experiments using human cells, BI-765423 effectively counteractes cellular senescence transformation, demonstrating potential anti-aging activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 146.61 kDa
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Color Colorless to light yellow
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SMILES
[BI-765423]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Pudewell S, et al. Targeting the major pro-inflammatory interleukin-6-type cytokine receptor gp130 by antagonistic single domain antibodies. Front Immunol. 2025 Aug 15;16:1613004. [Content Brief]
[2]. Zhavoronkov A, et al. Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis. Aging (Albany NY). 2025 Aug 16;17(8):1911-1928. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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