Camoteskimab
Based on 1 publication(s) in Google Scholar
Camoteskimab is a fully human monoclonal antibody with high affinity targeting IL-18. Camoteskimab is applicable to the research of autoinflammatory diseases.
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- Purity : 98.56%
- CAS No.: 2492472-82-7
- 분자량:146.34 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Camoteskimab
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Biological Activity
제품 설명
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
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IL-18 |
In Vitro
Camoteskimab potently neutralizes the activity of IL-18 in PBMC-based in vitro assays, with an IC50 in the sub-nanomolar range, and inhibits the formation of the IL-18/Ra/RB active complex[3].
Camoteskimab binds to human IL-18 with high affinity at 63 pM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1X106 A431 cells with Camoteskimab (HY-P99491, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2492472-82-7
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Appearance Liquid
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분자량 146.34 kDa
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Color Colorless to light yellow
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SMILES
[Camoteskimab]
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Synonyms
AVTX-007; CERC-007; MEDI 2338
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Eupafolin hinders cross-talk between gastric cancer cells and cancer-associated fibroblasts by abrogating the IL18/IL18RAP signaling axis. [Abstract]2024 Nov:134:155984. PMID: 39265444
순도&문서
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Data Sheet (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Bindoli S, et al. Adult-Onset Still's Disease (AOSD): Advances in Understanding Pathophysiology, Genetics and Emerging Treatment Options. Drugs. 2024;84(3):257-274. [Content Brief]
[2]. Chen X, et al. Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and Alzheimer's disease by bioinformatics analysis and machine learning. Front Aging Neurosci. 2024 Aug 27;16:1430290. [Content Brief]
[4]. Galozzi P, et al. Progress in Biological Therapies for Adult-Onset Still's Disease. Biologics. 2022;16:21-34. Published 2022 Apr 21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)