Anti-IL11 Antibody (X203, Mouse IgG)
Based on 1 Customer Validation
Anti-IL11 Antibody (X203, Mouse IgG) is an antibody targeting IL-11. Anti-IL11 Antibody (X203, Mouse IgG) inhibits IL-11-mediated activation of the ERK-mTORC1 axis, inactivation of LKB1-AMPK, and pro-senescence pathways. Anti-IL11 Antibody (X203, Mouse IgG) alleviates age-related metabolic decline, improves muscle function, reduces tissue fibrosis, decreases the expression of senescence markers, and maintains telomere length and mtDNA copy number. Anti-IL11 Antibody (X203, Mouse IgG) restores browning of white adipose tissue, upregulates thermogenic and mitochondrial biogenesis gene programs, reduces lipid droplet size, and decreases immune cell infiltration in visceral white adipose tissue. Anti-IL11 Antibody (X203, Mouse IgG) extends the median lifespan of mice and reduces the incidence of age-related tumors. Anti-IL11 Antibody (X203, Mouse IgG) can be used in the research of age-related metabolic decline, sarcopenia and age-related cancers.
For research use only. We do not sell to patients.
- Purity : 99.45%
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All AMPK Isoforms
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Biological Activity
Description
Isotype
Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
IL-11 |
In Vitro
Anti-IL11 Antibody (X203, Mouse IgG) can reactivate the thermogenic beige adipocyte program, enhance the activity of metabolic pathways, and suppress the expression of senescence and pro-inflammatory genes in inguinal white adipose tissue (vWAT), liver, and gastrocnemius muscle of aged male C57BL/6J mice in ex vivo experiments[1].
Anti-IL11 Antibody (X203, Mouse IgG) inhibits IL-11 signaling, reduces the activation level of the ERK-mTOR pathway, enhances AMPK activation, and decreases the expression of senescence markers in ex vivo experiments using primary epididymal white adipose tissue from aged male C57BL/6J mice[1].
Anti-IL11 Antibody (X203, Mouse IgG) reduces lipid droplet size, promotes beige adipocyte formation, and decreases macrophage infiltration in isolated inguinal white adipose tissue of aged male C57BL/6J mice[1].
Anti-IL11 Antibody (X203, Mouse IgG) reverses age-related tissue fibrosis in isolated inguinal white adipose tissue (vWAT), liver and gastrocnemius muscle of aged male C57BL/6J mice[1].
Anti-IL11 Antibody (X203, Mouse IgG) maintains telomere length and mitochondrial DNA copy number in ex vivo liver, gastrocnemius muscle and epididymal white adipose tissue (vWAT) of aged male C57BL/6J mice[1].
Anti-IL11 Antibody (X203, Mouse IgG) reduces fat mass and liver weight in ex vivo tissues of aged male C57BL/6J mice, while increasing their skeletal muscle and brown adipose tissue weight[1].
Anti-IL11 Antibody (X203, Mouse IgG) improves liver function, reduces circulating lipid and pro-inflammatory cytokine levels, and decreases hepatic triglyceride content in in vitro serum and liver tissue samples from aged male C57BL/6J mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 75-week-old, aged model)[1]
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Dosage:40 mg/kg
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Administration:i.p.; once every 3 weeks; 25 weeks
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Result:Drove progressive body weight loss via reduced indexed fat mass.
Improved glucose metabolism by decreasing GTT and ITT AUC compared to baseline.
Prevented frailty progression.
Increased full body grip strength compared to controls and baseline.
Increased respiratory exchange ratio, reducing age-associated metabolic inflexibility.
Increased core body temperature and food intake.
Reduced serum cholesterol, triglycerides, IL-6, and ALT levels.
Reduced liver triglyceride content and indexed liver mass.
Increased indexed gastrocnemius mass.
Reduced indexed vWAT mass.
Reversed tissue fibrosis in liver, gastrocnemius, and vWAT.
Reduced ERK-mTOR pathway activation and senescence marker (p16, p21) expression in vWAT.
Preserved telomere length and mtDNA copy number.
Upregulated thermogenic/beiging genes (Ucp1, Acot2, Cidea, Cox4i1, Cox8b, Dio2, Elovl3, Eva1a, Fabp3, Ppargc1a, Ppargc1b, Ppara, Prdm16) and mitochondrial biogenesis/function genes in vWAT.
Reduced expression of senescence and pro-inflammatory genes in vWAT, liver, and gastrocnemius.
Reduced vWAT lipid droplet area by 2.5-fold with fewer CD68+ macrophages.
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Animal Model:C57BL/6J (male, 75-week-old, aged model)[1]
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Dosage:40 mg/kg
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Administration:i.p.; monthly; until death
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Result:Extended median lifespan of male mice by 22.5% (median lifespan: IgG control 130.3 weeks, X203 159.6 weeks).
Reduced the incidence of macroscopic tumours.
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Animal Model:C57BL/6J (female, 75-week-old, aged model)[1]
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Dosage:40 mg/kg
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Administration:i.p.; monthly; until death
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Result:Extended median lifespan of female mice by 25% (median lifespan: IgG control 117.1 weeks, X203 146.4 weeks).
Reduced the incidence of macroscopic tumours.
Gene ID
Accession
Target
IL-11
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Anti-IL11 Antibody (X203, Mouse IgG)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)