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製品番号: HY-184444

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CDK4-IN-7

CDK4-IN-7 is a CDK4 inhibitor with an IC₅₀ of 26 nM. CDK4-IN-7 shows selectivity for CDK1, with an IC₅₀ of 4.2262 μM. CDK4-IN-7 can be used in cancer research.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3113087-01-4
分子式: C₂₀H₂₈F₂N₆O₂S
分子量:454.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK4-IN-7 構造式

CAS 番号: 3113087-01-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CDK4-IN-7 is a CDK4 inhibitor with an IC₅₀ of 26 nM. CDK4-IN-7 shows selectivity for CDK1, with an IC₅₀ of 4.2262 μM. CDK4-IN-7 can be used in cancer research^[1].

IC₅₀ & Target

^[1]

CDK4

26 nM (IC₅₀)

CDK1

4.2262 μM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

CDK4-IN-7 (Compound 5) potently inhibits CDK4 with an IC₅₀ of 26 nM and shows 162.5-fold selectivity for CDK4 over CDK1 in a biochemical kinase assay measuring retinoblastoma protein Ser⁷⁸⁰ phosphorylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

化学情報

CAS 番号 3113087-01-4
分子量 454.54
分子式 C₂₀H₂₈F₂N₆O₂S
SMILES

CC1=CC2=CN=C(N[C@H]3[C@H](F)CN(S(C4CC4)(=O)=O)CC3)N=C2N1[C@@H]5CCNC[C@@H]5F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Jiang, Y., & Liang, S. H. (2026). Pyridine Derivatives as Cyclin-Dependent Kinase Inhibitors for the Treatment of Cancer. ACS Medicinal Chemistry Letters.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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