1. Autophagy
  2. Autophagy

Autophinib 

Cat. No.: HY-101920 Purity: 99.06%
Handling Instructions

Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

For research use only. We do not sell to patients.

Autophinib Chemical Structure

Autophinib Chemical Structure

CAS No. : 1644443-47-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
2 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Technical Information

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Description

Autophinib is a potent autophagy inhibitor, which can inhibit autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

IC50 & Target

IC50: 19 nM (VPS34), 40 nM (rapamycin-induced autophagy), 90 nM (starvation-induced autophagy)[1]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (86.52 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8841 mL 14.4204 mL 28.8409 mL
5 mM 0.5768 mL 2.8841 mL 5.7682 mL
10 mM 0.2884 mL 1.4420 mL 2.8841 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

346.73

Formula

C₁₄H₁₁ClN₆O₃

CAS No.

1644443-47-9

SMILES

CC1=CC(NC2=NC(OC3=CC=C([N+]([O-])=O)C=C3)=NC(Cl)=C2)=NN1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Autophinib
Cat. No.:
HY-101920
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Autophinib

Cat. No.: HY-101920