1. Autophagy
  2. ULK

ULK-101 

Cat. No.: HY-114490
Handling Instructions

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2 in vitro, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress.

For research use only. We do not sell to patients.

ULK-101 Chemical Structure

ULK-101 Chemical Structure

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500 mg Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2 in vitro, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

IC50 & Target

IC50: 1.6 nM (ULK1), 30 nM (ULK2)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1718 mL 10.8589 mL 21.7179 mL
5 mM 0.4344 mL 2.1718 mL 4.3436 mL
10 mM 0.2172 mL 1.0859 mL 2.1718 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

460.45

Formula

C₂₂H₁₆F₄N₄OS

SMILES

FC1=CC=C(C(C=N2)=CN3C2=C(C4=CSC(C(N[[email protected]@H](C5CC5)C(F)(F)F)=O)=C4)C=N3)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ULK-101
Cat. No.:
HY-114490
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ULK-101

Cat. No.: HY-114490