1. Autophagy
  2. ULK

MRT68921 hydrochloride 

Cat. No.: HY-100006A Purity: 99.71%
Data Sheet SDS Handling Instructions

MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM).

For research use only. We do not sell to patients.
MRT68921 hydrochloride Chemical Structure

MRT68921 hydrochloride Chemical Structure

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10 mM * 1 mL in Water USD 79 In-stock
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100 mg USD 564 In-stock
200 mg USD 1020 In-stock
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Description

MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM). IC50 value: 2.9/1.1 nM (ULK1/2) Target: ULK in vitro: MRT68921 potently inhibits ULK1 and ULK2 and block autophagy in cells. MRT68921 specifically blocks autophagic flux through ULK1 inhibition. MRT68921 is able to inhibit the WT-restored ATG13 phosphorylation and autophagy similarly to cells expressing endogenous ULK1. [1]

References
Molecular Weight

471.04

Formula

C₂₅H₃₅ClN₆O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O: 10 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.71%

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Product Name:
MRT68921 hydrochloride
Cat. No.:
HY-100006A
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