Copy Link Print Information

MRT68921 dihydrochloride

28 Cited Publications
Customer Review

Based on 28 publication(s) in Google Scholar

MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

  • Purity: 99.67%
  • CAS No.: 2080306-21-2
  • Formula: C25H36Cl2N6O
  • Molecular Weight:507.50
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

  • MRT68921 dihydrochloride Chemical Structure
    MRT68921 dihydrochloride Chemical Structure
  • Experimental Validation Results for MRT68921 dihydrochloride
  • Experimental Validation Results for MRT68921 dihydrochloride
  • Experimental Validation Results for MRT68921 dihydrochloride
  • Experimental Validation Results for MRT68921 dihydrochloride
  • Experimental Validation Results for MRT68921 dihydrochloride
CAS No.: 2080306-21-2
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of MRT68921 dihydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) MRT68921 dihydrochloride

More
Customer Validation & Images
IFWB
  • IF
  • WB
  • WB
  • IF
  • WB

All ULK Isoforms

More

All GSK-3 Isoforms

More

All Bcl-2 Family Isoforms

More
Keywords
100 mg

Get Quote In-stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • MRT68921 dihydrochloride Chemical Structure
    MRT68921 dihydrochloride Chemical Structure
    1/16
  • 1/16

    MRT68921 dihydrochloride purchased from MedChemExpress. Usage Cited in: Dev Cell. 2025 Jun 27:S1534-5807(25)00372-7. [Abstract]

    Customer Validation
     Confocal images of mCherry-GOLPH3-expressing U2OS cells. Cells were either untreated or treated with EBSS for 12 hours, in the presence or absence of MRT68921 (250 μM). Right: Quantification of the percentage of cells with dispersed mCherry-GOLPH3. A total of 300 cells for each sample were quantified. n = 3. Scale bar: 10 µm.

  • 1/16

    MRT68921 dihydrochloride purchased from MedChemExpress. Usage Cited in: Dev Cell. 2025 Jun 27:S1534-5807(25)00372-7. [Abstract]

    Customer Validation
     Inhibition of EBSS-induced mCherry-GOLPH3 cleavage by ULK1 inhibitor MRT68921 (250 μM). U2OS cells transfected with the mCherry-GOLPH3 plasmid were left untreated or treated with EBSS, in the presence or absence of MRT68921 for 8 hours.

  • 1/16

    MRT68921 dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     TC-1 cells were pretreated with 1 μM MRT68921 for 1 h, followed by NP treatment for 24 h. MRT68921 inhibited the upregulation of NP-induced p-ULK1, ATG5, and LC3-II and the downregulation of SQSTM1 and GPX4.

  • 1/16

    MRT68921 dihydrochloride purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Aug 3:118658. [Abstract]

    Customer Validation
     MRT68921 (MRT, 5 μM; 2 h) attenuates the accumulation of LC3-II, thereby reducing YB treatment-induced necroptosis.

  • 1/16

    MRT68921 dihydrochloride purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123. [Abstract]

    Customer Validation
     The effects of two ULK1 inhibitors, ULK-101 (1 μM) and MRT68921 (1 μM), on levels of phospho-ATG14 (Ser29), ATG14, LC3-I/II, HGPRT, and 5′-NT in OA-treated A549 cells. The results showed that both ULK1 inhibitors rapidly downregulated phosphorylated ATG14 at Ser29, a well-established substrate of ULK1, reduced LC3-II isoform expression, and stabilized HGPRT and 5′-N.

  • MRT68921 dihydrochloride