Copy Link Print Information

MRT68921 hydrochloride

30 Cited Publications
Customer Review

Based on 30 publication(s) in Google Scholar

MRT68921 hydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 hydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 hydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 hydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 hydrochloride can be used for the research of cancer, such as breast cancer.

For research use only. We do not sell to patients.

  • CAS No.: 2070014-87-6
  • Formula: C25H35ClN6O
  • Molecular Weight:471.04
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • MRT68921 hydrochloride Chemical Structure
    MRT68921 hydrochloride Chemical Structure
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
  • Experimental Validation Results for MRT68921 hydrochloride
CAS No.: 2070014-87-6
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of MRT68921 hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Purity & Documentation
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) MRT68921 hydrochloride

More
Customer Validation & Images
Bio/Physico-chemical AssayIFCell Proliferation/Viability AssayIn Vivo Efficacy StudyWB
  • IF
  • WB
  • WB
  • IF
  • Bio/Physico-chemical Assay
  • IF
  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
  • Cell Proliferation/Viability Assay
  • WB

All ULK Isoforms

More

All GSK-3 Isoforms

More

All Bcl-2 Family Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • MRT68921 hydrochloride Chemical Structure
    MRT68921 hydrochloride Chemical Structure
    1/16
  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Dev Cell. 2025 Jun 27:S1534-5807(25)00372-7. [Abstract]

    Customer Validation
     Confocal images of mCherry-GOLPH3-expressing U2OS cells. Cells were either untreated or treated with EBSS for 12 hours, in the presence or absence of MRT68921 (250 μM). Right: Quantification of the percentage of cells with dispersed mCherry-GOLPH3. A total of 300 cells for each sample were quantified. n = 3. Scale bar: 10 µm.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Dev Cell. 2025 Jun 27:S1534-5807(25)00372-7. [Abstract]

    Customer Validation
     Inhibition of EBSS-induced mCherry-GOLPH3 cleavage by ULK1 inhibitor MRT68921 (250 μM). U2OS cells transfected with the mCherry-GOLPH3 plasmid were left untreated or treated with EBSS, in the presence or absence of MRT68921 for 8 hours.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     TC-1 cells were pretreated with 1 μM MRT68921 for 1 h, followed by NP treatment for 24 h. MRT68921 inhibited the upregulation of NP-induced p-ULK1, ATG5, and LC3-II and the downregulation of SQSTM1 and GPX4.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Dec 5:335:118658. [Abstract]

    Customer Validation
     MRT68921 (MRT, 5 μM; 2 h) attenuates the accumulation of LC3-II, thereby reducing YB treatment-induced necroptosis.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Nature. 2022 Oct;610(7931):366-372. [Abstract]

    Customer Validation
     KPC cells plated on wild-type or R/R ECM or plastic were incubated in CM or LG medium with or without EIPA, MBQ-167 (MBQ), MRT68921 dihydrochloride (MRT, 600 nM), EIPA + MRT or MBQ + MRT for 24 h.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 May 10;39(5):678-693.e11. [Abstract]

    Customer Validation
     Autophagosomes and macropinosomes in MIA PaCa-2 cells treated +/− MRT68921 dihydrochloride (600 nM). Scale bar, 10 μm.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 May 10;39(5):678-693.e11. [Abstract]

    Customer Validation
     KC6141 cells were incubated with vehicle, the ULK1/2 inhibitor MRT68921 dihydrochloride (MRT, 600 nM), EIPA or MRT + EIPA and total viable cells were measured.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 May 10;39(5):678-693.e11. [Abstract]

    Customer Validation
     C57BL/6 mice bearing KC6141 tumors or Nude mice bearing 1334 and 1444 allografts were treated with vehicle, MRT68921 dihydrochloride, EIPA, or MRT68921 dihydrochloride (10 mg/kg)+ EIPA for 3 weeks or 15 days. Whereas MRT68921 dihydrochloride or EIPA alone had a small effect on KC6141 or 1444 or 1334 tumor growth, the two agents together strongly inhibited tumors.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2021 May;2(5):503-514. [Abstract]

    Customer Validation
     Cell growth inhibition in KL and KP cells in response to autophagy inhibitors chloroquine (CQ) or ULK1 inhibitor MRT68921 dihydrochloride (MRT). Data shown represents one of three independent experiments. n=3 cell cultures for each cell line with each treatment condition.

  • 1/16

    MRT68921 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123. [Abstract]

    Customer Validation
     The effects of two ULK1 inhibitors, ULK-101 (1 μM) and MRT68921 (1 μM), on levels of phospho-ATG14 (Ser29), ATG14, LC3-I/II, HGPRT, and 5′-NT in OA-treated A549 cells. The results showed that both ULK1 inhibitors rapidly downregulated phosphorylated ATG14 at Ser29, a well-established substrate of ULK1, reduced LC3-II isoform expression, and stabilized HGPRT and 5′-N.

  • MRT68921 hydrochloride