Copy Link Print Information

Buparlisib Hydrochloride

(Synonyms: BKM120 Hydrochloride; NVP-BKM120 Hydrochloride)
90 Cited Publications
Customer Review

Based on 90 publication(s) in Google Scholar

Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.51%
  • CAS No.: 1312445-63-8
  • Formula: C18H22ClF3N6O2
  • Molecular Weight:446.85
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Buparlisib Hydrochloride Chemical Structure
    Buparlisib Hydrochloride Chemical Structure
  • Experimental Validation Results for Buparlisib Hydrochloride
  • Experimental Validation Results for Buparlisib Hydrochloride
  • Experimental Validation Results for Buparlisib Hydrochloride
  • Experimental Validation Results for Buparlisib Hydrochloride
  • Experimental Validation Results for Buparlisib Hydrochloride
  • Experimental Validation Results for Buparlisib Hydrochloride
CAS No.: 1312445-63-8
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Buparlisib Hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Protocol
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Buparlisib Hydrochloride

More
Customer Validation & Images
WB
  • WB
  • WB
  • WB
  • WB
  • WB
  • WB

All PI3K Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Buparlisib Hydrochloride Chemical Structure
    Buparlisib Hydrochloride Chemical Structure
    1/16
  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2019 Jan:440-441:54-63. [Abstract]

    Customer Validation
     The cells are transfected with either the negative control (siNC) or BTF3 siRNA for 12 hours followed by BKM-120 or AZD-6482 treatment for 48 hours. The protein abundance is determined by an immunoblotting analysis.

  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Jul 5;13(7):e0200014. [Abstract]

    Customer Validation
     Representative immunoblots of control and NHARAS treated with Buparlisib for 24 h.

  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Behav. 2018 Nov;8(11):e01123. [Abstract]

    Customer Validation
     The effect of BKM120 on AKT phosphorylation is examined by Western blot.

  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: Prostate. 2018 Feb;78(3):166-177. [Abstract]

    Customer Validation
     Western blot analysis of p-AKT (Ser473) in stable cell lines (Vector-DU145 and GOLM1-DU145) treated with 200 nM, 500 nM or 1 μM BKM120.

  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Med. 2016 Jul;22(7):723-6. [Abstract]

    Customer Validation
     Selective response of HER2-positive PDX DF-BM355 to the combination of BKM120/RAD001. Western blot analysis of lysates from vehicle-treated or BKM120-treated DF-BM355 in vivo.

  • 1/16

    Buparlisib Hydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2016 Jul 7;35(27):3607-12. [Abstract]

    Customer Validation
     (A) Immunoblot analyses in HCC1569 cells treated with BYL719, KIN193 (MedChemexpress) or BKM120 (μM). (B, C) Immunoblot analyses in BT474 and BT474-shPTEN cells treated as indicated in (A).

  • Buparlisib Hydrochloride