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Cat. No.: HY-15180R

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Buparlisib Hydrochloride (Standard)

(Synonyms: BKM120 Hydrochloride (Standard); NVP-BKM120 Hydrochloride (Standard))

Buparlisib (Hydrochloride) (Standard) is the analytical standard of Buparlisib (Hydrochloride). This product is intended for research and analytical applications. Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.

For research use only. We do not sell to patients.

Purity: 98%
CAS No.: 1312445-63-8
Formula: C₁₈H₂₂ClF₃N₆O₂
Molecular Weight:446.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Buparlisib Hydrochloride (Standard) Chemical Structure

CAS No.: 1312445-63-8

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1312445-63-8
Molecular Weight 446.85
Formula C₁₈H₂₂ClF₃N₆O₂
SMILES

NC(N=C1)=CC(C(F)(F)F)=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=C2.[H]Cl
Synonyms

BKM120 Hydrochloride (Standard); NVP-BKM120 Hydrochloride (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. [Content Brief]

[2]. Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Buparlisib Hydrochloride (Standard)

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Buparlisib Hydrochloride (Standard)

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Buparlisib Hydrochloride (Standard) Related Classifications

HY-15180R Related Classifications