1312445-63-8
1312445-63-8
Chemical Structure
Buparlisib Hydrochloride
Synonym(s): BKM120 Hydrochloride; NVP-BKM120 Hydrochloride
- CAS No.: 1312445-63-8
- Formula:C18H22ClF3N6O2
- Molecular Weight:446.85
IUPAC Name: 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine hydrochloride
InChIKey: DGPLYAXBXJXEID-UHFFFAOYSA-N
SMILES: NC(N=C1)=CC(C(F)(F)F)=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=C2.[H]Cl
Biological Activity: Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Buparlisib Hydrochloride | 99.51% | Buparlisib Hydrochloride (BKM120 Hydrochloride) is a CNS-penetrant pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively. | ||||||||||||||||||||
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Buparlisib Hydrochloride (Standard) | ≥98% | Buparlisib (Hydrochloride) (Standard) is the analytical standard of Buparlisib (Hydrochloride). This product is intended for research and analytical applications. Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.99
HY-70063Buparlisib -
Similarity Score 0.73
HY-12868Bimiralisib -
Similarity Score 0.58
HY-107365RPQR530 (Standard) -
Similarity Score 0.58
HY-167876PQR514 -
Similarity Score 0.57
HY-146260NVP-CLR457 -
Similarity Score 0.56
HY-755114,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine -
Similarity Score 0.53
HY-150618PI3Kα-IN-9 -
Similarity Score 0.52
HY-157180WAY-327131 -
Similarity Score 0.50
HY-153129EP2 receptor antagonist-2 -
Explore the MedChemAI to find more analogs
