PQR514

Cat. No.: HY-167876 Purity: 97.73%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors.

For research use only. We do not sell to patients.

PQR514 Chemical Structure

CAS No. : 1927857-55-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

394.38

Formula

C₁₆H₂₀F₂N₈O₂

CAS No.

1927857-55-3

Appearance

Solid

Color

White to off-white

SMILES

FC(C1=NC(N)=NC=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (126.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5356 mL	12.6781 mL	25.3563 mL
5 mM	0.5071 mL	2.5356 mL	5.0713 mL
10 mM	0.2536 mL	1.2678 mL	2.5356 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (250 KB) HNMR (115 KB) LCMS (161 KB)

Handling Instructions (2659 KB)

References

[1]. Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5356 mL	12.6781 mL	25.3563 mL	63.3906 mL
	5 mM	0.5071 mL	2.5356 mL	5.0713 mL	12.6781 mL
	10 mM	0.2536 mL	1.2678 mL	2.5356 mL	6.3391 mL
	15 mM	0.1690 mL	0.8452 mL	1.6904 mL	4.2260 mL
	20 mM	0.1268 mL	0.6339 mL	1.2678 mL	3.1695 mL
	25 mM	0.1014 mL	0.5071 mL	1.0143 mL	2.5356 mL
	30 mM	0.0845 mL	0.4226 mL	0.8452 mL	2.1130 mL
	40 mM	0.0634 mL	0.3170 mL	0.6339 mL	1.5848 mL
	50 mM	0.0507 mL	0.2536 mL	0.5071 mL	1.2678 mL
	60 mM	0.0423 mL	0.2113 mL	0.4226 mL	1.0565 mL
	80 mM	0.0317 mL	0.1585 mL	0.3170 mL	0.7924 mL
	100 mM	0.0254 mL	0.1268 mL	0.2536 mL	0.6339 mL

PQR514 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PQR5141927857-55-3PQR 514PQR-514PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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PQR514

PQR514 Related Antibodies

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