1927857-55-3
Chemical Structure
PQR514
- CAS No.: 1927857-55-3
- Formula:C16H20F2N8O2
- Molecular Weight:394.38
InChIKey: VZVYLEDIUUZTCW-UHFFFAOYSA-N
SMILES: FC(C1=NC(N)=NC=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)F
Biological Activity: PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors[1].
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PQR514 | 97.73% | PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors. | ||||||||||||||||||||
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Keywords
