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Cat. No.: HY-107365R

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PQR530 (Standard)

Name: PQR530 (Standard)
Brand: MedChemExpress
SKU: HY-107365R
Price: 150.00 USD
Availability: InStock
Rating: 5 (1 reviews)

PQR530 (Standard) is the analytical standard of PQR530 (HY-107365). This product is intended for research and analytical applications. PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar K_d toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity.

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CAS No.: 1927857-61-1
Formule: C₁₈H₂₃F₂N₇O₂
Masse moléculaire:407.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

PQR530 (Standard) Chemical Structure

CAS No.: 1927857-61-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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PI3K/mTORC1/2^[1]

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Chemical Information

CAS No. 1927857-61-1
Masse moléculaire 407.42
Formule C₁₈H₂₃F₂N₇O₂
SMILES

FC(C1=CC(N)=NC=C1C2=NC(N3CCOCC3)=NC(N4[C@H](COCC4)C)=N2)F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Denise Rageot, et al. Abstract 140: Discovery and biological evaluation of PQR530, a highly potent dual pan-PI3K/mTORC1/2 inhibitor. Cancer Res 2017;77(13 Suppl).

[2]. Rageot D, et al. (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. J Med Chem. 2019;62(13):6241-6261. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PQR530 (Standard)

Voir tous les produits spécifiques à Isoform PI3K

Voir tous les produits spécifiques à Isoform mTOR

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