1. PI3K/Akt/mTOR
  2. PI3K
    mTOR
  3. PQR-530

PQR-530 

Cat. No.: HY-107365
Handling Instructions

PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity.

For research use only. We do not sell to patients.

PQR-530 Chemical Structure

PQR-530 Chemical Structure

CAS No. : 1927857-61-1

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Description

PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity.

IC50 & Target[1]

PI3K

 

mTORC1

 

mTORC2

 

In Vitro

PQR-530 is a potent, oral and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, exhibiting antitumor activity. PQR-530 inhibits all PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 µM in A2058 melanoma cells. PQR-530 shows inhibitory activity against the growth of 44 cancer cell lines with mean GI50 of 426 nM[1].

Molecular Weight

407.42

Formula

C₁₈H₂₃F₂N₇O₂

CAS No.

1927857-61-1

SMILES

FC(C1=CC(N)=NC=C1C2=NC(N3CCOCC3)=NC(N4[[email protected]](COCC4)C)=N2)F

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PQR-530
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