1. PI3K/Akt/mTOR
  2. PI3K

Duvelisib (Synonyms: IPI-145; INK1197)

Cat. No.: HY-17044 Purity: 99.63%
Handling Instructions

Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.

For research use only. We do not sell to patients.

Duvelisib Chemical Structure

Duvelisib Chemical Structure

CAS No. : 1201438-56-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg USD 252 In-stock
Estimated Time of Arrival: December 31
100 mg USD 312 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Duvelisib:

    Duvelisib purchased from MCE. Usage Cited in: Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

    Western blot analysis of selected MAPK and AKT/mTOR pathway components in Trametinib- and Temsirolimus-treated cells.

    Duvelisib purchased from MCE. Usage Cited in: Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093.

    Western blot analysis of selected MAPK and AKT/mTOR pathway components in Trametinib- and Temsirolimus-treated cells.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Duvelisib is a selectivite p100δ inhibitor with IC50 of 2.5 nM, 27.4 nM, 85 nM and 1602 nM for p110δ, P110γ, p110β and p110α, respectively.

    IC50 & Target[2]

    p110δ

    2.5 nM (IC50)

    p110γ

    27.4 nM (IC50)

    p110β

    85 nM (IC50)

    p110α

    1602 nM (IC50)

    In Vitro

    PI3Kδ and PI3Kγ inhibition with IPI-145 has anti-proliferative activity in primary AML cells by inhibiting the activity of AKT and MAPK. Pre-treatment of AML cells with IPI-145 inhibits both adhesion and migration of AML blasts to bone marrow stromal cells[1]

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 41 mg/mL (98.35 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3989 mL 11.9944 mL 23.9889 mL
    5 mM 0.4798 mL 2.3989 mL 4.7978 mL
    10 mM 0.2399 mL 1.1994 mL 2.3989 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    416.86

    Formula

    C₂₂H₁₇ClN₆O

    CAS No.

    1201438-56-3

    SMILES

    O=C1N(C2=CC=CC=C2)C([[email protected]@H](NC3=C4N=CNC4=NC=N3)C)=CC5=C1C(Cl)=CC=C5

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.63%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
    Duvelisib
    Cat. No.:
    HY-17044
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    Duvelisib

    Cat. No.: HY-17044