1. PI3K/Akt/mTOR
  2. PI3K
  3. Sonolisib

Sonolisib (Synonyms: PX-866)

Cat. No.: HY-N6775 Purity: >99.0%
Handling Instructions

Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity.

For research use only. We do not sell to patients.

Sonolisib Chemical Structure

Sonolisib Chemical Structure

CAS No. : 502632-66-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 486 In-stock
Estimated Time of Arrival: December 31
1 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity[1][2].

IC50 & Target[1] [1] [1] [1] [2]

p110α

0.1 nM (IC50)

p110δ

2.9 nM (IC50)

p120γ

1 nM (IC50)

In Vitro

Sonolisib (PX-866) inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations[3].

Molecular Weight

525.59

Formula

C₂₉H₃₅NO₈

CAS No.

502632-66-8

SMILES

O=C1C([[email protected]@](CC2)([H])[[email protected]@]3(C)C2=O)=C([[email protected]](OC(C)=O)C3)[[email protected]]4(C)C(/C(C(O[[email protected]@H]4COC)=O)=C\N(CC=C)CC=C)=C1O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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