1225037-39-7
1225037-39-7
Chemical Structure
Bimiralisib
Synonym(s): PQR309
- CAS No.: 1225037-39-7
- Formula:C17H20F3N7O2
- Molecular Weight:411.38
IUPAC Name: 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
InChIKey: ADGGYDAFIHSYFI-UHFFFAOYSA-N
SMILES: NC1=NC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C(C(F)(F)F)=C1
Biological Activity: Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. Bimiralisib is an mTORC1 and mTORC2 inhibitor.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bimiralisib | 98.62% | Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. Bimiralisib is an mTORC1 and mTORC2 inhibitor. | ||||||||||||||||||||
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Keywords
