1. Epigenetics
    TGF-beta/Smad
  2. PKC

Ruboxistaurin hydrochloride (Synonyms: LY333531 hydrochloride; LY-333531 hydrochloride; LY 333531 hydrochloride)

Cat. No.: HY-10195B Purity: 99.54%
Data Sheet SDS Handling Instructions

Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily.

For research use only. We do not sell to patients.
Ruboxistaurin hydrochloride Chemical Structure

Ruboxistaurin hydrochloride Chemical Structure

CAS No. : 169939-93-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO $211 In-stock
1 mg $50 In-stock
5 mg $190 In-stock
10 mg $350 In-stock
25 mg $750 In-stock
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Description

Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily. target: PKC β1/β2 [1] IC50: 4.7 ( PKCβI ), 5.9 nM ( PKCβII ) In vivo: A significant up-regulation of TGF-b1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin.

References
M.Wt

505.01

Formula

C₂₈H₂₉ClN₄O₃

CAS No.

169939-93-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 6.8 mg/mL (Need ultrasonic and warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ruboxistaurin hydrochloride
Cat. No.:
HY-10195B
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