1. Epigenetics
    TGF-beta/Smad
  2. PKC

Ruboxistaurin hydrochloride (Synonyms: LY 333531 hydrochloride)

Cat. No.: HY-10195B Purity: 99.54%
Handling Instructions

Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily.

For research use only. We do not sell to patients.
Ruboxistaurin hydrochloride Chemical Structure

Ruboxistaurin hydrochloride Chemical Structure

CAS No. : 169939-93-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 253 In-stock
1 mg USD 60 In-stock
5 mg USD 228 In-stock
10 mg USD 420 In-stock
25 mg USD 900 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

    Ruboxistaurin hydrochloride purchased from MCE. Usage Cited in: Biosci Rep. 2018 Feb 12. pii: BSR20171459.

    Western blots analysis showing protein expression level of phosphorylated p-PKC βII over total PKC βII and total H3Cit over total H3 in wounds 12 days post wounding
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Ruboxistaurin hydrochloride is a isozyme-selective inhibitor of protein kinase C (PKC), a competitive reversible inhibitors of PKCβI and PKCβII with IC50 value of 4.7 nM and 5.9 nM respectivily. target: PKC β1/β2 [1] IC50: 4.7 ( PKCβI ), 5.9 nM ( PKCβII ) In vivo: A significant up-regulation of TGF-b1, Smad2 and Smad3 mRNA expression was observed in diabetic rats, which was alleviated by administration of ruboxistaurin.

    Clinical Trial
    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 1.9802 mL 9.9008 mL 19.8016 mL
    5 mM 0.3960 mL 1.9802 mL 3.9603 mL
    10 mM 0.1980 mL 0.9901 mL 1.9802 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    505.01

    Formula

    C₂₈H₂₉ClN₄O₃

    CAS No.

    169939-93-9

    SMILES

    O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[[email protected]](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.[H]Cl

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO: 6.8 mg/mL (Need ultrasonic and warming)

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Inquiry Information

    Product Name:
    Ruboxistaurin hydrochloride
    Cat. No.:
    HY-10195B
    Quantity: