1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Bisindolylmaleimide XI hydrochloride

Bisindolylmaleimide XI hydrochloride (Synonyms: Ro 32-0432; Ro 31-8830 hydrochloride)

Cat. No.: HY-117610A
Handling Instructions

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively.

For research use only. We do not sell to patients.

Bisindolylmaleimide XI hydrochloride Chemical Structure

Bisindolylmaleimide XI hydrochloride Chemical Structure

CAS No. : 145333-02-4

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Description

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is a potent, selective and orally active PKC inhibitor with IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCε, respectively[1][2].

IC50 & Target[1]

PKC-α

9 nM (IC50)

PKC-βI

28 nM (IC50)

PKC-βII

31 nM (IC50)

PKC-γ

37 nM (IC50)

PKC-ε

108 nM (IC50)

In Vitro

Bisindolylmaleimide XI hydrochloride (Ro 32-0432) inhibits IL-2 secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Bisindolylmaleimide XI hydrochloride[2].
PKC inhibition with Bisindolylmaleimide XI hydrochloride (Ro 32-0432; 1 μM) decreases the proportion of apoptotic cells (-21%) in retinal progenitor cells (RPCs)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

489.01

Formula

C₂₈H₂₉ClN₄O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
Bisindolylmaleimide XI hydrochloride
Cat. No.:
HY-117610A
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