192050-59-2
Chemical Structure
Ruboxistaurin mesylate
Synonym(s): LY333531 mesylate
- CAS No.: 192050-59-2
- Formula:C29H32N4O6S
- Molecular Weight:564.65
IUPAC Name: (12E,32E,7S)-7-((dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione methanesulfonate
InChIKey: DUHQBKLTAVUXFF-FERBBOLQSA-N
SMILES: O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[C@H](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.CS(=O)(O)=O
Biological Activity: Ruboxistaurin (LY333531) mesylate is an orally active, selective and ATP competitive PKCβ inhibitor with IC50 values of 4.7 and 5.9 nM for PKCβI and PKCβII, respectively. Ruboxistaurin mesylate can be used for the research of eye disorders, heart failure and diabetes[1][2][3][4].
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Ruboxistaurin mesylate | 98.93% | Ruboxistaurin (LY333531) mesylate is an orally active, selective and ATP competitive PKCβ inhibitor with IC50 values of 4.7 and 5.9 nM for PKCβI and PKCβII, respectively. Ruboxistaurin mesylate can be used for the research of eye disorders, heart failure and diabetes. | ||||||||||||||||||||
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Similarity Score 0.93
HY-10195Ruboxistaurin -
Similarity Score 0.93
HY-10195BRuboxistaurin hydrochloride -
Similarity Score 0.81
HY-10195BSRuboxistaurin-d6 hydrochloride -
Similarity Score 0.71
HY-136679TD114-2 -
Similarity Score 0.69
HY-13866Ro 31-8220 mesylate -
Similarity Score 0.67
HY-129624ABisindolylmaleimide VIII acetate -
Similarity Score 0.66
HY-129624Bisindolylmaleimide VIII -
Similarity Score 0.65
HY-13867ARBisindolylmaleimide I hydrochloride (Standard) -
Similarity Score 0.64
HY-13867Bisindolylmaleimide I -
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References
- [1]. Jirousek MR, et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem. 1996;39(14):2664-2671. [Content Brief]
- [2]. Ruboxistaurin: LY 333531. Drugs R D. 2007;8(3):193-199. [Content Brief]
- [3]. Kunt T, et al. The beta-specific protein kinase C inhibitor ruboxistaurin (LY333531) suppresses glucose-induced adhesion of human monocytes to endothelial cells in vitro. J Diabetes Sci Technol. 2007 Nov;1(6):929-35. [Content Brief]
- [4]. Nonaka A, et al. PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2702-6. [Content Brief]
