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Cat. No.: HY-P12125

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TAT-Epsilon-V1-2 TFA

TAT-Epsilon-V1-2 TFA is a cell-permeable PKCε peptide inhibitor. TAT-Epsilon-V1-2 TFA reduces chronic immune responses after heart transplantation. TAT-Epsilon-V1-2 TFA is applicable to research related to delayed graft function and acute kidney injury caused by renal ischemia-reperfusion injury.

For research use only. We do not sell to patients.

Formula: C₁₀₁H₁₈₁N₄₁O₂₆·xC₂HF₃O₂
Molecular Weight:2385.78 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TAT-Epsilon-V1-2 TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PKCε

All PKC Isoforms :

In Vitro

TAT-Epsilon-V1-2 TFA links the PKCε inhibitory peptide sequence (εV1‑2) to the TAT protein transduction domain, which facilitates the molecule's penetration through cell membranes.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2385.78 (free base)
Formula C₁₀₁H₁₈₁N₄₁O₂₆·xC₂HF₃O₂
SMILES

O=C(O)C(F)(F)F.O=C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N.[x]
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr
Sequence Shortening

YGRKKRRQRRREAVSLKPT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marrocco V, et al. PKC and PKN in heart disease. Journal of molecular and cellular cardiology. 2019 Mar;128:212-226. [Content Brief]

[2]. Sleeper S, et al. Myristoylated Protein Kinase C Epsilon Inhibitor Preserves Renal Function in a Mouse Model of Acute Bilateral Kidney Ischemia-Reperfusion Injury.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TAT-Epsilon-V1-2 TFA

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TAT-Epsilon-V1-2 TFA Related Classifications

HY-P12125 Related Classifications